Evidence map›Paper›PMID 40883571›Full record

ArticleNature immunology2025

Single-cell atlas of human liver and blood immune cells across fatty liver disease stages reveals distinct signatures linked to liver dysfunction and fibrogenesis.

Owen P Martin, Michael S Wallace, Christopher Oetheimer, Hailey B Patel, Michael D Butler, Lai Ping Wong, Pinzhu Huang, Joshua Elbaz, Charlotte Costentin, Shadi Salloum and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
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  9. Article
  10. Article
  11. Article
  12. Article
  13. Regulatory T cells safeguard liver health during metabolic-associated steatohepatitis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  14. [Advances in research on metabolic associated fatty liver disease in 2025].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  15. [Advances in basic and experimental diagnostic research on liver diseases in 2025​].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Owen P MartinDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0002-5014-0039
Michael S WallaceDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9679-6546
Christopher OetheimerDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Hailey B PatelDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Michael D ButlerDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0005-2210-8922
Lai Ping WongDepartment of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Pinzhu HuangDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8339-9701
Joshua ElbazDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Charlotte CostentinDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Shadi SalloumDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Zoe ReinusDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Adaeze ObineloDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Ulandt KimDepartment of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Stuti ShroffDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1674-2557
Kathleen E CoreyDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Yury V PopovDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Edgar D CharlesBristol Myers Squibb, Lawrenceville, NJ, USA.
Ruslan I SadreyevDepartment of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Raymond T ChungDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Nadia AlatrakchiDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. nalatrakchi@mgh.harvard.edu.ORCID http://orcid.org/0000-0001-7600-564X

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
HIV-Hepatitis C Virus Cooperative Interactions and Liver Disease ProgressionR01DK098079 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHUNG, RAYMOND T · 2013 to 2016
$2.7M
Mitochondrial DAMPs-driven Mechanisms of Liver Fibrosis in NASHR01DK139288 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Yury Popov · 2024 to 2026
$2.0M
HIV-induced monocyte and macrophage perturbations driving liver fibrogenesisR56DK134251 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI ALATRAKCHI, NADIA, CHUNG, RAYMOND T · 2022 to 2022
$651k
NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R01 DK098079NIDDK NIH HHS R01 DK139288NIDDK NIH HHS R56 DK134251U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK098079U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R56DK134251
6 · The paper itself

Abstract

Immune cells play a central yet poorly understood role in metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis (MASLD/MASH), a global cause of liver disease with limited treatment. Limited access to human livers and lack of studies across MASLD/MASH stages thwart identification of stage-specific immunological targets. Here we provide a unique single-cell RNA sequencing atlas of paired peripheral blood and liver fine-needle aspirates from a full-spectrum MASLD/MASH human cohort. Our findings included heightened immunoregulatory programs with MASH progression, such as enriched hepatic regulatory T cells, monocytic myeloid-derived suppressor cells, TREM2

Indexed as

Fatty LiverLiverLiver CirrhosisAdultDisease ProgressionFemaleHumansKiller Cells, NaturalMacrophagesMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseReceptors, ImmunologicSingle-Cell AnalysisT-Lymphocytes, RegulatoryReceptors, Immunologic

Identifiers

PMID40883571
PMCPMC12818073

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.