Evidence map›Paper›PMID 40883566›Full record

SynthesisInternational journal of obesity (2005)2025

Effect of vagus nerve stimulation on metabolism: a systematic review and meta-analysis.

Tianxiao Shen, Xinyue Tang, Yixin Pan, Hua He, Kejia Hu

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tianxiao Shen *Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0009-0002-5140-0293
Xinyue Tang *Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yixin PanDepartment of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hua HeDepartment of Neurosurgery, The Third Affiliated Hospital, Naval Medical University, Shanghai, China.
Kejia HuDepartment of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. dockejiahu@gmail.com.ORCID http://orcid.org/0000-0003-4036-5197

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVagus Nerve Stimulation (VNS) has long been a standard surgical procedure for patients with treatment-resistant depression or epilepsy. However, several studies have confirmed a side-effect of VNS treatment as weight loss. Animal model studies (e.g., rats, minipigs) and clinical trials have shown promising outcomes regarding weight and appetite, but further statistical analysis is limited.

methodsWe searched PubMed and several databases for rat model studies, minipig model studies, and human trials between 1966 and March 2024. All reported changes in weight, appetite, and energy expenditure were assessed. Meta-analysis was employed to calculate the overall pooled effects across studies with different durations or measurements.

resultsOf the 529 papers identified, 15 studies were eligible for this meta-analysis, including 12 animal trials and 4 human randomized controlled trials (RCTs). VNS showed a significant effect on reducing weight gain in both animal models (rats 95% CI -0.91 to -0.27, I

conclusionVNS has demonstrated notable impacts on reducing weight, suppressing appetite, and enhancing energy expenditure in rat and minipig models, indicating a promising therapeutic application in addressing metabolic disorders. Human trials also showed the effectiveness and safety of VNS on metabolism.

Indexed as

Energy MetabolismVagus Nerve StimulationAnimalsDisease Models, AnimalHumansRatsSwineSwine, MiniatureWeight Loss

Identifiers

PMID40883566

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.