Evidence map›Paper›PMID 40883549›Full record

ArticleAnnals of biomedical engineering2025

Image-Guided Adaptive Cryotherapy for Prostate Cancer Treatment.

Eva Beek, Nobuhiko Hata, Kemal Tuncali, Pedro Moreira

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eva BeekDepartment of Radiology, Brigham & Women's Hospital, Harvard Medical School, 75 Francis St., Boston, 02115, MA, USA. e.x.beek@student.tue.nl.ORCID http://orcid.org/0009-0003-8709-6980
Nobuhiko HataDepartment of Radiology, Brigham & Women's Hospital, Harvard Medical School, 75 Francis St., Boston, 02115, MA, USA. hata@bwh.harvard.edu.
Kemal TuncaliDepartment of Radiology, Brigham & Women's Hospital, Harvard Medical School, 75 Francis St., Boston, 02115, MA, USA.
Pedro MoreiraDepartment of Radiology, Brigham & Women's Hospital, Harvard Medical School, 75 Francis St., Boston, 02115, MA, USA. plopesdafrotamoreira@bwh.harvard.edu.

Funding

TRD 3 - Enabling Technologies for Intraprocedural GuidanceP41EB028741 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI Oliver Jonas · 2021 to 2026
$10.7M
Adaptive Percutaneous Prostate Interventions using Sensorized NeedleR01CA235134 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Nobuhiko Hata, IULIAN IOAN IORDACHITA · 2019 to 2026
$3.6M
Physician Assistance Technology in Image-guided Robotic Intervention of ProstateR01EB030539 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI HATA, NOBUHIKO, ZHANG, HAICHONG · 2021 to 2024
$2.7M
NCI NIH HHS R01 CA235134NIBIB NIH HHS P41 EB028741NIBIB NIH HHS P41EB028741NIBIB NIH HHS R01CA235134NIBIB NIH HHS R01 EB030539NIBIB NIH HHS R01EB030539
6 · The paper itself

Abstract

purposeFocal cryoablation is an effective treatment for localized and recurrent prostate cancer, offering reduced risks of side effects. However, treatment success depends on physician experience, as intraprocedural adjustments are required due to needle deflection. To determine whether an image-guided adaptive treatment strategy could reduce the required years of experience, we developed Image-guided Adaptive Cryotherapy (ImAC). We hypothesize that ImAC can be successfully implemented in MRI-guided cryotherapy to optimize needle placement. To test this hypothesis, we conducted a retrospective study comparing the performance of an experienced physician to that of ImAC.

methodsImAC was designed to calculate the best subsequent needle location while accounting for needle deflection and iceball formation. After development, its performance was evaluated by simulating 21 needle insertions.

resultsWe found that ImAC achieved a higher median minimum ablation margin than the physician (5.0 vs 3.4 mm) while maintaining similar needle placement adjustments (± 7.5 mm).

conclusionThese results suggest that ImAC has the potential to optimize needle placement and may reduce the years of experience required for effective cryoablation.

Indexed as

CryosurgeryCryotherapyProstatic NeoplasmsSurgery, Computer-AssistedHumansMagnetic Resonance ImagingMaleRetrospective Studies3D SlicerAdaptive needle placementFocal cryoablationMRI-guided cryoablationProstate cancer

Identifiers

PMID40883549
PMCPMC12461749

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.