Evidence map›Paper›PMID 40883546›Full record

ArticleJournal of cancer survivorship : research and practice2025

Decision-making experience for second donation in unrelated hematopoietic stem cell donors: a descriptive qualitative study.

Hangting Li, Lingxi Chen, Dijiong Wu, Jiayin Ruan, Xiaolian Wu

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In one paragraph

Article in Journal of cancer survivorship : research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. How prevalent is fear of cancer recurrence beyond 5 years: a systematic review of validated assessments across tumour types.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  3. "I felt as though my life had come to an end": lived experiences of adolescents and young adults with cancer in Nepal.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  4. Relationships among fear of progression, avoidance coping, and post-traumatic growth in adult patients with lymphoma: A multi-center cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hangting LiHematology Department, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Lingxi ChenSchool of Nursing, Zhejiang Chinese Medical University, Hangzhou, China.
Dijiong WuHematology Department, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Jiayin RuanRory Meyers College of Nursing, New York University, New York, NY, USA.
Xiaolian WuHematology Department, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China. 810158612@qq.com.

Funding

Research Project of Zhejiang Chinese Medical University 2022JKJNTZ21Zhejiang Provincial Medical and Health Science Research Project 2023RC041
6 · The paper itself

Abstract

backgroundA second allogeneic hematopoietic stem cell transplantation (allo-HSCT) is often the most effective treatment option for patients experiencing graft failure or disease relapse following a first round of allo-HSCT. Unfortunately, the consent rate for second donation is insufficient to meet treatment needs worldwide. The purpose of this study was to provide a comprehensive understanding of the decision-making experience of unrelated donors when considering making a second donation. This research is essential as it could inform the development of interventions to improve the consent rate for second donation.

designThis was a descriptive qualitative study that followed the COREQ checklist.

methodsA total of 16 unrelated hematopoietic stem cell donors who completed a second donation were selected by purposive sampling and underwent semi-structured interviews between September and December 2023. Data were analyzed using conventional content analysis.

resultsData analysis yielded four themes and 11 sub-themes: (1) initial reaction (unexpectedness, immediate consent); (2) locked-in dilemma (worried about the outcome of second donation, faced familial pressure, felt morally hijacked); (3) internal impetus (personal value of helping others, kinship tie, self-efficacy from the first donation, positive impact of the first donation), and (4) external reinforcement (pluralistic social support and societal influence).

conclusionsTo improve the consent rate for second donations, it is necessary to implement targeted education and comprehensive support encompassing personal, familial, and social aspects, while ensuring autonomy. Our analysis suggested that optimizing the first donation experience and fostering positive feedback beliefs are crucial factors when considering a second donation. IMPLICATIONS FOR CANCER SURVIVORS: By clarifying the decision-making experiences of unrelated donors, this research informs strategies to improve second donation consent rates. Enhanced donor retention directly expands life-saving options for patients with disease relapse or graft failure, potentially improving survival outcomes.

Indexed as

Decision-makingExperienceInterviewQualitative studySecond donationUnrelated hematopoietic stem cell donor

Identifiers

PMID40883546

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.