Evidence map›Paper›PMID 40883506›Full record

ArticleThe EMBO journal2025

Cytosolic DNA crosstalk in senescence: a new axis of inflammatory signaling?

Zhixun Dou, Jill A Kreiling, Susanne Heynen-Genel, Diana Jurk, Nicola Neretti, Peter D Adams, John M Sedivy, João F Passos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. The immunology behind inflammaging-causes, sources, and mechanisms.The Journal of allergy and clinical immunology · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Mitochondrial DNA as a driver of inflammation via the cGAS-STING pathway.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhixun DouKrantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3069-3907
Jill A KreilingCenter on the Biology of Aging, and the Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, 225 Dyer Street, Providence, RI, 02903, USA.ORCID http://orcid.org/0000-0003-4440-2039
Susanne Heynen-GenelSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Diana JurkRobert and Arlene Kogod Center on Aging and the Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.
Nicola NerettiCenter on the Biology of Aging, and the Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, 225 Dyer Street, Providence, RI, 02903, USA.
Peter D AdamsSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
John M SedivyCenter on the Biology of Aging, and the Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, 225 Dyer Street, Providence, RI, 02903, USA.
João F PassosRobert and Arlene Kogod Center on Aging and the Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA. passos.joao@mayo.edu.ORCID http://orcid.org/0000-0001-8765-1890

Funding

Somatic Activation of Retrotransposition: A New Molecular Mechanism of Aging?P01AG051449 · NIA · BROWN UNIVERSITY · PI John M Sedivy · 2016 to 2026
$30.4M
Targeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, Nathan K LeBrasseur · 2019 to 2026
$28.7M
STRUCTURAL BASIS FOR EPIGENETICS IN AGING AND LONGEVITYP01AG031862 · NIA · WISTAR INSTITUTE · PI ZHANG, RUGANG · 2008 to 2022
$28.3M
MECHANISMS OF REPLICATIVE SENESCENCE IN CELLSR01AG016694 · NIA · BROWN UNIVERSITY · PI SEDIVY, JOHN M · 1999 to 2024
$5.7M
Salivary Extracellular Vesicles as Biomarkers for Alzheimer's Disease and Related DisordersR01AG074284 · NIA · BROWN UNIVERSITY · PI Jill Kreiling, lori A daiello · 2022 to 2026
$3.9M
Defining molecular contributions of LINE-1 retrotransposons to AD / ADRDR01AG078925 · NIA · ROCKEFELLER UNIVERSITY · PI John LaCava, John M Sedivy · 2022 to 2026
$3.7M
Autophagy degradation of nuclear and chromatin constituentsR35GM137889 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI Zhixun Dou · 2020 to 2026
$2.6M
Cytoplasmic chromatin fragments in cell senescence - novel mechanisms and interventionsR01AG071861 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ADAMS, PETER D. · 2021 to 2025
$2.3M
Nucleus-to-cytoplasm trafficking of chromatin fragments in senescence and agingR01AG082785 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Zhixun Dou · 2023 to 2026
$2.2M
The role of sub-lethal mitochondrial apoptotic stress in cellular senescenceR01AG068048 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2020 to 2024
$2.2M
Does obesity exacerbate age-related cognitive decline via senescence?R01AG068182 · NIA · MAYO CLINIC ROCHESTER · PI JURK, DIANA · 2020 to 2024
$2.0M
Investigating the role of cytosolic mitochondrial double-stranded RNA in cellular senescence and agingR01AG082708 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2023 to 2025
$1.5M
HHS | National Institutes of Health (NIH) P01AG031862,R01AG071861HHS | National Institutes of Health (NIH) P01AG062413, R01AG078925HHS | National Institutes of Health (NIH) R01AG016694,R01AG078,P01AG051449 925HHS | National Institutes of Health (NIH) R01AG068048,R01AG82708,UG3/UH3CA268103 08HHS | National Institutes of Health (NIH) R01AG068182HHS | National Institutes of Health (NIH) R01AG074284HHS | National Institutes of Health (NIH) R01AG082785,R35GM137889,UG3/UH3CA268117HHS | National Institutes of Health (NIH) UG3/UH3CA268202NCI NIH HHS UG3 CA268103NIA NIH HHS P01 AG031862NIA NIH HHS P01 AG051449NIA NIH HHS P01 AG062413NIA NIH HHS R01 AG016694NIA NIH HHS R01 AG068048NIA NIH HHS R01 AG068182NIA NIH HHS R01 AG071861NIA NIH HHS R01 AG074284NIA NIH HHS R01 AG078925NIA NIH HHS R01 AG082708NIA NIH HHS R01 AG082785NIGMS NIH HHS R35 GM137889
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40883506
PMCPMC12489115

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.