Encapsulating Pt NCs with an AIE effect into a metal-organic framework as a novel fluorescence nanoprobe for discriminatively detecting bisphosphonate drugs.

Juan Du, Jinwen Chen, Huixiao Tong, Shenghua Liao

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In one paragraph

Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

4 authors.

Juan DuDepartment of Analytical Chemistry, School of Science, China Pharmaceutical University, Nanjing, 211198, Jiangsu, People's Republic of China.

Jinwen ChenDepartment of Analytical Chemistry, School of Science, China Pharmaceutical University, Nanjing, 211198, Jiangsu, People's Republic of China.

Huixiao TongDepartment of Analytical Chemistry, School of Science, China Pharmaceutical University, Nanjing, 211198, Jiangsu, People's Republic of China.

Shenghua LiaoDepartment of Analytical Chemistry, School of Science, China Pharmaceutical University, Nanjing, 211198, Jiangsu, People's Republic of China. liaoshenghua@cpu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluorescent metal organic frameworks (FMOFs) constructed by encapsulating aggregation-induced emission luminogens (AIEgens) into frameworks have garnered increasing attention due to their ability to overcome the aggregation-caused quenching (ACQ) effect of traditional fluorescent materials such as organic dyes, quantum dots, and up-conversion nanoparticles. However, conventional AIEgens usually contain aromatic groups that may pose potential health risks. Additionally, the quality of bisphosphonates (BPs), first-line treatment drugs in skeletal-related diseases, is critical to assure their effectiveness and safety. In this work, a new nanocomposite, Pt NCs@ZIF-8, was designed by encapsulating platinum nanoclusters (Pt NCs) with aggregation-induced emission (AIE) properties into zeolitic imidazolate framework-8 (ZIF-8) through self-assembly between Zn

Indexed as

DiphosphonatesFluorescent DyesMetal NanoparticlesMetal-Organic FrameworksPlatinumHumansLimit of DetectionSpectrometry, FluorescenceZeolitesDiphosphonatesFluorescent DyesMetal-Organic FrameworksPlatinumZeolitesAggregation-induced emissionBisphosphonatesFluorescence quenchingMetal–organic frameworkPlatinum nanoclustersPrincipal component analysis

Identifiers

PMID40883497

DOI10.1002/bio.3622

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.