Photonic resonator absorption microscopy: why consider metallic and magneto-plasmonic nano-assemblies over bare nanoparticles for digital biosensing?

Skye Shepherd, Weinan Liu, Seemesh Bhaskar, Brian T Cunningham

Abstract read

In one paragraph

Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Skye Shepherd *Nick Holonyak Jr. Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

Weinan Liu *Nick Holonyak Jr. Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

Seemesh BhaskarNick Holonyak Jr. Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. seemeshb@illinois.edu.ORCID http://orcid.org/0000-0003-2714-3776

Brian T CunninghamNick Holonyak Jr. Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. bcunning@illinois.edu.

Funding

National Science Foundation CBET 22-32681NIH HHS R33 CA27227

6 · The paper itself

Abstract

The unique optical interaction of species such as nanomaterials, proteins, viruses, antibodies, microRNA, and exosomes with the one-dimensional grating-based photonic crystals (PCs) has been leveraged in their detection using photonic crystal absorption microscopy (PRAM). While the principle and fundamental mechanism of such interfacial interactions are well delineated using wavelength and intensity modulations associated with the guided-mode resonance (GMR) of the PC, the effect of nano-assemblies in place of nanoparticles (NPs) has not been reported previously. In this work, the fundamental limitations observed with pristine NPs are overcome through the use of tunable AuNP assemblies synthesized via adiabatic cooling technology, where tunable nano-assemblies are obtained by subjecting the respective NPs to - 196 °C. Moreover, the higher contrast rendered by magneto-plasmonic, Fe

Indexed as

Biosensing TechniquesGoldMetal NanoparticlesMicroRNAsMicroscopyPhotonsSurface Plasmon ResonanceGoldMicroRNAsCOMSOLCryosoretEnhanced absorptionGuided-mode resonanceMagnetic hotspotPhotonic crystal

Identifiers

PMID40883496

DOI10.1007/s00216-025-06056-y

PMCPMC12680894

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