ArticleScientific reports2025
Development of a smart polymer film based on hydrogen-bonded organic frameworks: stimuli-responsive and ammonia sensing.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Integrating Multifunctional Hydrogen-Bonded Organic Frameworks into Intelligent Packaging: Mechanisms, Design and Challenges.Materials (Basel, Switzerland) · 2026Review
- Hydrogel Films in Biomedical Applications: Fabrication, Properties and Therapeutic Potential.Gels (Basel, Switzerland) · 2025Review
- Development of a smart polymer film based on hydrogen-bonded organic frameworks: stimuli-responsive and ammonia sensing.Scientific reports · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
A multifunctional polyvinyl alcohol (PVA) film integrated with a Metronidazole.hydrogen-bonded organic framework (MET.HOF) encapsulating metronidazole was developed. The stability of MET.HOF is to temperature and pH-sensitive variations, leading to the controlled release of metronidazole under such conditions. Additionally, the incorporation of anthocyanin into the polymer matrix imparts the ability to detect ammonia, as anthocyanin exhibits color changes in response to pH fluctuations. Consequently, this film serves as a temperature/pH-responsive smart wound dressing. To assess the drug release behavior, the film's responsiveness was tested at different pH levels (5.5, 7.4, and 9) and temperatures (37 °C and 40 °C), conditions representative of wound environments. The results demonstrated that the polymer film effectively released metronidazole at temperatures above 37 °C and under alkaline pH, allowing for tailored drug delivery based on wound conditions. Anthocyanin functioned as a natural pH indicator, enabling the detection of ammonia produced at infected wound sites. The polymer's color change was quantitatively analyzed using RGB color detection software, with a minimum detectable concentration of 1.25 ± 0.07 mg L
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Registered trials
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