Evidence map›Paper›PMID 40883431›Full record

ArticleScientific reports2025

Loneliness among emerging adults in rural reservation-based communities: longitudinal effects of 12th grade substance use and mental health symptoms.

Caroline M Barry, Ashna Jagtiani, Juli R Skinner, Ashley N Gassaway, Kelli A Komro, Melvin D Livingston

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Understanding the Association Between Substance Use and Loneliness in Midlife and Older Adults.International journal of environmental research and public health · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Caroline M BarryRollins School of Public Health, Emory University, Atlanta, GA, USA. caroline.m.barry@dartmouth.edu.
Ashna JagtianiRollins School of Public Health, Emory University, Atlanta, GA, USA.
Juli R SkinnerCherokee Nation Behavioral Health, Tahlequah, OK, USA.
Ashley N GassawayCherokee Nation Behavioral Health, Tahlequah, OK, USA.
Kelli A KomroRollins School of Public Health, Emory University, Atlanta, GA, USA.
Melvin D LivingstonRollins School of Public Health, Emory University, Atlanta, GA, USA.

Funding

Community Randomized Trial in the Cherokee Nation: CONNECT and CMCA for Preventing Drug Misuse among Older AdolescentsUH3DA050234 · NIDA · EMORY UNIVERSITY · PI KOMRO, KELLI ANN, LIVINGSTON, MELVIN D · 2020 to 2023
$4.9M
Training in the Science of Co-Occurring DisordersT32DA037202 · NIDA · DARTMOUTH COLLEGE · PI Lisa A. Marsch · 2014 to 2026
$4.7M
Training in Advanced Data Analytics to End Drug-Related Harms (TADA)T32DA050552 · NIDA · EMORY UNIVERSITY · PI Howard H Chang, Hannah LF Cooper · 2020 to 2026
$1.6M
NIDA NIH HHS T32 DA037202NIDA NIH HHS T32 DA050552NIDA NIH HHS UH3 DA050234NIDA NIH HHS UH3DA050234
6 · The paper itself

Abstract

Loneliness is a growing public concern among emerging adults, yet little is known about its predictors in rural and reservation-based communities. This study examines whether substance use and mental health symptoms in 12th grade predict loneliness post high school among a rural reservation-based sample. Participants (n = 483) were surveyed in 12th grade (Spring 2024) and again six months into young adulthood (Fall 2024). Independence estimating equations with a Poisson distribution were used to assess the effect of past 30-day substance use (alcohol use, binge drinking, cannabis use, vaping cannabis, and vaping nicotine) and past 2-week mental health (anxiety and depressive symptoms) on loneliness after high school. Substance use and mental health symptoms in 12th grade were significant predictors of post high school loneliness. Alcohol use, binge drinking, cannabis use, and vaping nicotine or cannabis were each associated with a 21-24% increased risk of loneliness. Five-point increases in anxiety and depressive symptoms respectively were associated with 15% and 21% greater risk of loneliness. Prevention efforts targeting substance use and mental health before high school graduation may help reduce the risk of loneliness among rural reservation-based young people as they enter adulthood.

Indexed as

LonelinessMental HealthRural PopulationSubstance-Related DisordersAdolescentAdultAlcohol DrinkingAnxietyDepressionFemaleHumansLongitudinal StudiesMaleYoung AdultAmerican indianEmerging adultsLonelinessMental healthRuralSubstance use

Identifiers

PMID40883431
PMCPMC12397287

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.