ArticleNPJ breast cancer2025
Prognostic and predictive capacity of tumor infiltrating lymphocytes in the MA.20 regional node radiotherapy trial.
Article in NPJ breast cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- The MHCII Immune Activation Score predicts risk of recurrence and benefit of taxanes in Basallike and HER2-enriched breast cancer.medRxiv : the preprint server for health sciences · 2026Article
- Immune Cell Composition and Prognosis in Node-Positive, Irradiated Breast Cancer Patients in the DBCG-IMN2 Study.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Article
- Prognostic relevance of increased tumor-infiltrating lymphocytes in residual TNBC following neoadjuvant chemotherapy.BMC cancer · 2025Article
- Prognostic value of tumor-infiltrating lymphocytes in irradiated node-positive breast cancer patients.Breast (Edinburgh, Scotland) · 2025Article
- Individualising radiation therapy decisions in breast cancer patients based on tumour infiltrating lymphocytes and genomic biomarkers.Breast (Edinburgh, Scotland) · 2023Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Prognostic and predictive value of immune infiltrates in the context of regional nodal radiation (RNI) for breast cancer has not been assessed. Stromal tumor infiltrating lymphocytes (sTILs) were assessed on scanned images of hematoxylin and eosin (H&E) stained sections and by CD8 immunohistochemistry on tissue microarrays available from the MA.20 trial. Cox proportional modelling was used, and hazard ratios (HR) with 95% confidence intervals (CI) are reported for primary and secondary endpoints. Predictive value was assessed by an interaction test. H&E sTILs (continuous parameter) were prognostic for distant-DFS (HR 0.99, 95% CI 0.98-1.00, P = 0.04). CD8+sTILs were associated with significantly improved disease-free survival (DFS) (HR 0.99, 95% CI 0.98-1.00, P = 0.02) and distant-DFS (HR 0.98, 95% CI 0.97-0.99, P = 0.0002). CD8+sTILs was predictive of benefit from RNI for distant-DFS (continuous variable: HR 0.98, 95% CI 0.96-1.00, P
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.