Evidence map›Paper›PMID 40883285›Full record

ArticleNPJ Parkinson's disease2025

Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis.

Jessica Pei, Nathalia L Oliveira, Sherilyn J Recinto, Alexandra Kazanova, Celso M Queiroz-Junior, Ziyi Li, Katalina Couto, Susan Westfall, Ahmed M Fahmy, Camila Tiefensee-Ribeiro and 6 more

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In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Tissue-specific transcriptional epistasis between Prkn and Lrrk2 during mycobacterial infection.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Jessica Pei *Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-7115-5606
Nathalia L Oliveira *Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-5823-2184
Sherilyn J RecintoAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.ORCID http://orcid.org/0000-0001-9632-1201
Alexandra KazanovaDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-4850-9845
Celso M Queiroz-JuniorDepartamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Ziyi LiDepartment of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.
Katalina CoutoDepartment of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.
Susan WestfallDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada.
Ahmed M FahmyAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.ORCID http://orcid.org/0000-0003-0444-383X
Camila Tiefensee-RibeiroAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.ORCID http://orcid.org/0000-0003-0876-119X
Irah L KingDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada.
Austen J MilnerwoodMontreal Neurological Institute, McGill University, Montreal, QC, Canada.
Michel DesjardinsAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.ORCID http://orcid.org/0000-0002-5684-5980
Ajitha ThanabalasuriarDepartment of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.
Jo Anne StrattonAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. jo.stratton@mcgill.ca.ORCID http://orcid.org/0000-0002-1205-1353
Samantha GruenheidDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada. samantha.gruenheid@mcgill.ca.ORCID http://orcid.org/0000-0002-0908-6715

Funding

Aligning Science Across Parkinson's ASAP-000525CIHR PJT 162406
6 · The paper itself

Abstract

Parkinson's Disease (PD) is a neurodegenerative disorder often preceded by gastrointestinal dysfunction. Mutations in leucine-rich repeat kinase 2 (LRRK2) are known risk factors for both PD and inflammatory bowel disease (IBD), suggesting a link between PD and the gastrointestinal tract. Using single-cell RNA-sequencing and spectral flow cytometry, we demonstrated that the Lrrk2 Gly2019Ser (G2019S) mutation is associated with an increased neutrophil presence in the colonic lamina propria during Citrobacter rodentium infection. This concurred with a Th17 skewing, upregulated Il17a, and greater colonic pathology during infection. In vitro experiments showed enhanced kinase-dependent neutrophil chemotaxis and neutrophil extracellular trap (NET) formation in Lrrk2 G2019S mice compared to wild-type counterparts. Our results add to the understanding of LRRK2-driven immune cell dysregulation and its contribution to PD, offering insights into potential biomarkers for early diagnosis and intervention in PD.

Identifiers

PMID40883285
PMCPMC12397289

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.