ArticleBritish journal of anaesthesia2026
Age-related sex differences in intensive care treatment and outcomes: a nationwide cohort study.
Article in British journal of anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Timing matters: sex differences in treatment limitation decisions in intensive care.Critical care (London, England) · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReported differences in treatment and mortality between male and female patients in the ICU are inconsistent. Previous studies suggest that age might influence sex differences, partly explaining earlier discrepancies. This study aimed to compare patient characteristics, care intensity, and mortality between male and female ICU patients while examining potential age-varying sex differences.
methodsAll adult (≥18 yr) ICU patients between 2012 and 2024 were identified in the Swedish Intensive Care Registry. Multivariable logistic regression models, adjusted for age and Simplified Acute Physiology Score 3, investigated associations between patient sex and 30-day mortality, continuous renal replacement therapy, and invasive ventilation. Analyses included the entire cohort and six diagnostic subgroups. To describe the varying effect of sex across ages, a multivariable logistic regression model, using natural cubic splines, allowed age to interact with sex.
resultsWe included 303 875 ICU patients (median [interquartile range] age: 67 [51-76] yr; 42.8% female). Crude mortality was higher in male patients (odds ratio [OR] 0.94, confidence interval [CI] 0.92-0.95). In multivariable models, female sex was associated with higher 30-day mortality (OR 1.03, CI 1.01-1.05). Male patients were more likely to receive continuous renal replacement therapy and invasive ventilation. Female patients had lower mortality risk at younger ages and higher mortality risk at older ages.
conclusionsAlthough males constitute a larger proportion of ICU patients and receive more advanced treatments, females have higher adjusted mortality. This is nuanced by age-specific variations, which underscore the complexity and necessity of considering age when evaluating sex-based differences in ICU outcomes.
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