Evidence map›Paper›PMID 40883020›Full record

ArticleCancer genomics & proteomics

Insights from Tissue Inhibitor of Metalloproteinase-2 Genotypes to Decipher the Genetic Architecture of Childhood Acute Lymphocytic Leukemia Risk.

Pei-Chen Hsu, Chung-Lin Tsai, Jen-Sheng Pei, Chao-Chun Chen, Huey-En Tzeng, Te-Chun Hsia, Yun-Chi Wang, Hou-Yu Shih, Chia-Wen Tsai, DA-Tian Bau and 1 more

Abstract read
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Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pei-Chen Hsu *Department of Pediatrics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C.
Chung-Lin Tsai *Division of Cardiac and Vascular Surgery, Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
Jen-Sheng Pei *Department of Pediatrics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C.
Chao-Chun ChenDepartment of Pediatrics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C.
Huey-En TzengDivision of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
Te-Chun HsiaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Yun-Chi WangTerry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Hou-Yu ShihTerry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Chia-Wen TsaiTerry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.
DA-Tian BauTerry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.; 013280@tool.caaumed.org.tw 031002@tool.caaumed.org.tw.
Wen-Shin ChangTerry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.; 013280@tool.caaumed.org.tw 031002@tool.caaumed.org.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimAcute lymphoblastic leukemia (ALL) is the most common pediatric hematologic malignancy, particularly affecting children aged 2~5 years. Tissue inhibitor of metalloproteinase-2 (TIMP-2), a key regulator of MMP-2 activity, has been implicated in several cancers, yet its genetic role in childhood ALL remains unexplored. MATERIALS AND

methodsThis study investigated four

results

conclusion

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotidePrecursor Cell Lymphoblastic Leukemia-LymphomaTissue Inhibitor of Metalloproteinase-2Case-Control StudiesChildChild, PreschoolFemaleGene FrequencyGenotypeHumansInfantMalePrognosisRisk FactorsTaiwanTIMP2 protein, humanTissue Inhibitor of Metalloproteinase-2Childhood leukemiagenotypepolymorphismtissue inhibitor of metalloproteinase-2

Identifiers

PMID40883020
PMCPMC12402721

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.