Evidence map›Paper›PMID 40883017›Full record

ArticleGenes & development2025

MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis.

Jonathon M Muncie-Vasic, Tanvi Sinha, Alexander P Clark, Emily F Brower, Jeffrey J Saucerman, Brian L Black, Benoit G Bruneau

Abstract read
In one paragraph

Article in Genes & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jonathon M Muncie-VasicGladstone Institutes, San Francisco, California 94158, USA.ORCID 0000-0002-7405-6213
Tanvi SinhaCardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158, USA.ORCID 0000-0001-9509-5687
Alexander P ClarkDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22904, USA.ORCID 0000-0002-5200-6573
Emily F BrowerGladstone Institutes, San Francisco, California 94158, USA.
Jeffrey J SaucermanDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22904, USA.ORCID 0000-0001-9464-8374
Brian L BlackCardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158, USA.ORCID 0000-0002-6664-8913
Benoit G BruneauGladstone Institutes, San Francisco, California 94158, USA; benoit.bruneau@gladstone.ucsf.edu.ORCID 0000-0002-0804-7597

Funding

BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6M
Early Cardiac ProgenitorsR01HL114948 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI Benoit Gaetan Bruneau · 2013 to 2026
$7.5M
Systems Pharmacology Model of Cardiac HypertrophyR01HL162925 · NHLBI · UNIVERSITY OF VIRGINIA · PI SAUCERMAN, JEFFREY J., WOLF, MATTHEW J · 2022 to 2025
$3.1M
Computational and Experimental Modeling of Cardiomyocyte ProliferationR01HL160665 · NHLBI · UNIVERSITY OF VIRGINIA · PI SAUCERMAN, JEFFREY J., VAN BERLO, JOHANNES (JOP) · 2022 to 2025
$2.8M
Gene regulatory networks for heart developmentR01HL155906 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BRUNEAU, BENOIT GAETAN · 2021 to 2024
$2.4M
EXTRAMULAR RESEARCH FACILITIES CONSTRUCTIONC06RR018928 · NCRR · J. DAVID GLADSTONE INSTITUTES · PI MAHLEY, ROBERT W. · 2003 to 2003
$2.1M
Transcriptional control of endocardial-specific gene expressionR01HL177462 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian L Black · 2025 to 2026
$1.1M
Illumina NovaSeq 6000 Sequencing SystemS10OD028511 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHOW, ERIC D · 2020 to 2020
$583k
Defining the Cellular Morphogenic Behaviors that Shape the Developing HeartF32HL162450 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI MUNCIE-VASIC, JONATHON MICHAEL · 2022 to 2023
$137k
NCRR NIH HHS C06 RR018928NHLBI NIH HHS F32 HL162450NHLBI NIH HHS R01 HL114948NHLBI NIH HHS R01 HL155906NHLBI NIH HHS R01 HL160665NHLBI NIH HHS R01 HL162925NHLBI NIH HHS R01 HL177462NHLBI NIH HHS T32 HL007284NIH HHS S10 OD028511
6 · The paper itself

Abstract

The gene regulatory networks (GRNs) that control early heart formation are beginning to be understood, but lineage-specific GRNs remain largely undefined. We investigated networks controlled by the vital transcription factor MEF2C using a time course of single-nucleus RNA sequencing and ATAC sequencing in wild-type and

Indexed as

Gene Expression Regulation, DevelopmentalGene Regulatory NetworksHeartMEF2 Transcription FactorsMorphogenesisZebrafishZebrafish ProteinsAnimalsEnhancer Elements, GeneticMEF2 Transcription FactorsZebrafish Proteinscardiogenesisdevelopmental biologyembryogenesisgene regulationgene regulatory networksheart development

Identifiers

PMID40883017
PMCPMC12412991

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.