Evidence map›Paper›PMID 40882866›Full record

ArticleThe Journal of pediatrics2026

Clinical Course and Outcomes of Invasive Haemophilus influenzae Infections among Children at Two Hospitals in Alaska.

Victoria A Balta, Bionca Davis, Carolynn K DeByle, Christine Desnoyers, Marah Gotcsik, Benjamin Westley, Marc Fischer, Jonathan Steinberg

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Victoria A BaltaArctic Investigations Program, Division of Infectious Disease Readiness and Innovation, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA. Electronic address: uqs9@cdc.gov.
Bionca DavisArctic Investigations Program, Division of Infectious Disease Readiness and Innovation, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA.
Carolynn K DeByleArctic Investigations Program, Division of Infectious Disease Readiness and Innovation, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK.
Christine DesnoyersHealth Research Department, Yukon-Kuskokwim Health Corporation, Bethel, AK.
Marah GotcsikDepartment of Pediatrics, Alaska Native Medical Center, Anchorage, AK.
Benjamin WestleyDepartment of Pediatrics, Alaska Native Medical Center, Anchorage, AK.
Marc FischerArctic Investigations Program, Division of Infectious Disease Readiness and Innovation, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK.
Jonathan SteinbergArctic Investigations Program, Division of Infectious Disease Readiness and Innovation, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK.

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

objectiveOur objective was to compare the clinical course of invasive Haemophilus influenzae disease by type among children at 2 hospitals in Alaska. STUDY

designWe performed a retrospective review of invasive H. influenzae cases among Alaska children aged <10 years who received care at the Alaska Native Medical Center in Anchorage or the Yukon-Kuskokwim Delta Regional Hospital in Bethel, Alaska, during 2013-2019. Clinical and demographic data were obtained by medical record review. Categorical variables were compared with Fisher's exact test.

resultsWe identified 62 invasive H. influenzae infections, including 45 (73%) type a (Hia), 8 (13%) type b (Hib), 7 (11%) nontypeable (NTHi), and 2 (3%) type f (Hif). All children were Alaska Native. Overall, 43 (69%) cases occurred in previously healthy children with no underlying medical conditions. Nineteen (31%) children required intensive care and 13 (21%) died or still had clinical sequelae at 1 year postinfection. All deaths (n = 6) and long-term sequelae (n = 7) occurred in children with Hia or Hib meningitis. Children with NTHi were more likely to require respiratory support compared with children with Hia, Hib, or Hif (6/7, 86% vs 15/55, 27%) (P < .01).

conclusionsWe identified severe disease among Alaska Native children with invasive Hia, Hib, Hif, and NTHi infections. Hia and Hib caused more meningitis-associated fatalities, and NTHi caused more respiratory complications. Characterizing trends in invasive H. influenzae illness will help direct public health strategies, including the development and use of novel vaccines.

Indexed as

Haemophilus InfectionsHaemophilus influenzaeAlaskaAlaska NativesAnti-Bacterial AgentsChildChild, PreschoolFemaleHumansInfantMaleRetrospective StudiesAnti-Bacterial AgentsAlaskaAmerican Indian or Alaska Nativechilddisease progressionHaemophilus influenzae

Identifiers

PMID40882866
PMCPMC12608053

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.