Evidence map›Paper›PMID 40882635›Full record

ArticleCancer cell2025

Multi-omic profiling of intraductal papillary neoplasms of the pancreas reveals distinct patterns and potential markers of progression.

Yuefan Wang, Tung-Shing M Lih, Jae W Lee, Takao Ohtsuka, Yuto Hozaka, Mari Mino-Kenudson, Nazmi Volkan Adsay, Claudio Luchini, Aldo Scarpa, Ajay V Maker and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Yuefan WangDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Tung-Shing M LihDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Jae W LeeDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Takao OhtsukaDepartment of Digestive Surgery, Kagoshima University, Kagoshima 890-8520, Japan.
Yuto HozakaDepartment of Digestive Surgery, Kagoshima University, Kagoshima 890-8520, Japan.
Mari Mino-KenudsonDepartment of Pathology, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114, USA.
Nazmi Volkan AdsayDepartment of Pathology, Koç University School of Medicine, Istanbul 34010, Turkey.
Claudio LuchiniDepartment of Diagnostics and Public Health, Section of Pathology, ARC-Net Research Center, University and Hospital Trust of Verona, 37129 Verona, Italy.
Aldo ScarpaDepartment of Diagnostics and Public Health, Section of Pathology, ARC-Net Research Center, University and Hospital Trust of Verona, 37129 Verona, Italy.
Ajay V MakerDivision of Surgical Oncology, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Grace E KimDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Jorge PaulinoDepartment of Surgery, Hospital da Luz, 1500-650 Lisbon, Portugal.
Lijun ChenDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Jongmin WooDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Liyuan JiaoDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Zhenyu SunDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Davina GoodmanDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Michael J PflügerDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Surgery, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114, USA.
Nicholas J RobertsDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Oncology, Sol Goldman Pancreatic Cancer Research Center, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Hanno MatthaeiDepartment of Surgery, University Hospital of Bonn, 53127 Bonn, Germany.
Michael G GogginsDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Oncology, Sol Goldman Pancreatic Cancer Research Center, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Laura D WoodDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Oncology, Sol Goldman Pancreatic Cancer Research Center, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Toru FurukawaDepartment of Investigative Pathology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Hui ZhangDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Oncology, Sol Goldman Pancreatic Cancer Research Center, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: huizhang@jhu.edu.
Ralph H HrubanDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Oncology, Sol Goldman Pancreatic Cancer Research Center, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: rhruban@jhmi.edu.

Funding

Proteogenomic Characterization of Tumor Tissues and Preclinical Models with High PrecisionU24CA271079 · NCI · JOHNS HOPKINS UNIVERSITY · PI DANIEL Wanyui CHAN, Hui Zhang · 2022 to 2026
$6.6M
The Comprehensive Proteome Characterization Center at Johns Hopkins: High Precision Discovery and Confirmation of Genoproteomic TargetsU24CA210985 · NCI · JOHNS HOPKINS UNIVERSITY · PI CHAN, DANIEL WANYUI, ZHANG, HUI · 2016 to 2020
$5.3M
The ontogeny of segmental speech organizationR01DC000633 · NIDCD · UTAH STATE UNIVERSITY · PI NITTROUER, SUSAN · 1994 to 2015
$3.5M
Development of a panel of multiplex biomarkers for the early detection of pancreatic ductal adenocarcinoma and high-risk lesionsU01CA274514 · NCI · JOHNS HOPKINS UNIVERSITY · PI Randall Brand, DANIEL Wanyui CHAN · 2023 to 2026
$3.2M
NCI NIH HHS U01 CA274514NCI NIH HHS U24 CA210985NCI NIH HHS U24 CA271079NIDCD NIH HHS R01 DC000633
6 · The paper itself

Abstract

To enable early detection of pancreatic cancer from precancerous lesions, we analyze proteins and glycoproteins from 64 intraductal papillary mucinous neoplasms (IPMNs), 55 cyst fluid samples, 104 pancreatic ductal adenocarcinomas (PDACs), and various types of normal samples using mass spectrometry. High-grade IPMNs show enrichment of glycosylation level and tumor progression pathways compared to low-grade lesions. High-grade IPMN associated proteins, such as PLOD3, IRS2, LGALS9, and Trop-2, are identified and validated using immunolabeling and laser microdissection. Some high-grade associated proteins are also detected in pancreatic cyst fluids, which allows us to link proteins and glycoproteins expressed in neoplastic cells to clinically accessible biospecimens. Altered glycosylation level of extracellular matrix (ECM) proteins is observed in IPMNs compared to normal ducts. Additionally, we identify a subset of IPMNs with PDAC-like features, including elevated expression of ECM proteins. These findings offer insight into progression-associated proteins and emphasize the diagnostic and therapeutic potential of these proteins in pancreatic tumors.

Indexed as

Adenocarcinoma, MucinousBiomarkers, TumorCarcinoma, Pancreatic DuctalCarcinoma, PapillaryPancreatic Intraductal NeoplasmsPancreatic NeoplasmsAgedDisease ProgressionFemaleGlycoproteinsGlycosylationHumansMaleMiddle AgedMultiomicsProteomicsBiomarkers, TumorGlycoproteinsearly detectionextracellular matrixglycoproteomicsIPMNpancreatic cancerproteomicstumor progression

Identifiers

PMID40882635
PMCPMC12482137

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.