Evidence map›Paper›PMID 40882442›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2025

The neuroendocrine regulation of hepatic cytochrome P450 by N-methyl-D-aspartate receptors in the paraventricular and arcuate nuclei of the hypothalamus.

Renata Pukło, Ewa Bromek, Agnieszka Basińska-Ziobroń, Anna Haduch, Wojciech Kuban, Przemysław J Danek, Władysława A Daniel

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Article in Drug metabolism and disposition: the biological fate of chemicals, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Renata PukłoDepartment of Pharmacokinetics and Drug Metabolism, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Ewa BromekDepartment of Pharmacokinetics and Drug Metabolism, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Agnieszka Basińska-ZiobrońDepartment of Pharmacokinetics and Drug Metabolism, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Anna HaduchDepartment of Pharmacokinetics and Drug Metabolism, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Wojciech KubanDepartment of Pharmacokinetics and Drug Metabolism, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Przemysław J DanekDepartment of Pharmacokinetics and Drug Metabolism, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Władysława A DanielDepartment of Pharmacokinetics and Drug Metabolism, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland. Electronic address: nfdaniel@cyf-kr.edu.pl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our previous study showed that the antagonist of the GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor, the compound CP-101,606, negatively affected hepatic cytochrome P450 (P450) expression and activity after intraperitoneal administration. The aim of our current study was to demonstrate the effect of intracerebral administration of CP-101,606 into the paraventricular (PVN) or arcuate (ARC) nuclei of the hypothalamus on the central neuroendocrine regulation of P450. Male rats received bilateral injections of CP-101,606 into the PVN or ARC for 5 days. Hypothalamic, pituitary, and serum hormone levels, and the expression and activity of hepatic P450 enzymes were measured. Repeated injections of CP-101,606 into the PVN increased somatostatin levels in the PVN and pituitary, decreased serum growth hormone (GH) and corticosterone but raised T

Indexed as

Arcuate Nucleus of HypothalamusCytochrome P-450 Enzyme SystemLiverNeurosecretory SystemsParaventricular Hypothalamic NucleusReceptors, N-Methyl-D-AspartateAnimalsMaleRatsRats, WistarCytochrome P-450 Enzyme SystemReceptors, N-Methyl-D-AspartateHepatic cytochrome P450Intracerebral administrationNeuroendocrine regulationParaventricular and arcuate nucleiTraxoprodil (CP-101,606)

Identifiers

PMID40882442
PMCPMC12597568

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.