Observational studyNeurology2025
Features of Prodromal Parkinson Disease and Dopaminergic Neurotransmission in Community-Dwelling Older Adults.
Observational study in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Mapping the Silent Onset of Parkinson's Disease: Monoamine Imaging in the Era of the Race for Preclinical Intervention.Current neurology and neuroscience reports · 2026Review
- Acid sensing to inflammaging: mechanisms and therapeutic promise of GPR68 (OGR1) in aging-related diseases.Frontiers in aging · 2025Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesParkinson disease (PD) pathology begins years before clinical diagnosis. Identifying individuals in this prodromal period is of high priority because they are candidates for clinical trials. Several characteristics of the PD prodrome have been described, but many are nonspecific. Among community-dwelling older adults unselected for PD risk, their relationship to objective measures of nigrostriatal dopaminergic nerve terminal density has not been studied in vivo. We determined prevalence of PD risk factors and prodromal signs/symptoms in community-dwelling older adults, examined their relationship with dopaminergic nerve terminal density, and explored prevalence and distribution of other possible prodromal features.
methodsThis was a cross-sectional observational study of community-dwelling older adults without diagnosed neurologic disorders in Southwestern Pennsylvania. Participants were assessed for 5 PD risk markers and ≤8 prodromal signs/symptoms, and underwent dopaminergic imaging with dihydrotetrabenazine ([
resultsA total of 231 participants were included, mean (SD) age 75.1 (4.5) years, 94 (40.7%) men. More than 1 prodromal sign/symptom was present in 131 (56.7%), with cognitive deficit being the most common. pPD was present in 18 (7.8%) of the sample. Compared with the not pPD group, the pPD group had lower mean age-adjusted and sex-adjusted predicted [ DISCUSSION: Prodromal nonmotor and motor signs/symptoms of PD are common in community-dwelling older adults. Increased probability of prodromal PD is associated with decreased dopaminergic nerve terminal density of the posterior putamen that is also more asymmetric. Our findings support the use of composite measures of prodromal features to identify individuals at the population level who may be at risk for PD.
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