ArticleOptics letters2025
Indocyanine green (ICG) enhances penetration of 1300 nm optical coherence tomography imaging for
Article in Optics letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Tartrazine clearing of the tympanic membrane for improved visualization of the middle ear.Biomedical optics express · 2026Article
- Automated processing pipeline for functional imaging of human cardiac organoids using optical coherence tomography.Biomedical optics express · 2026Article
- Tartrazine Clears Live Cells while Preserving Viability at High Refractive Indices and Osmolality.Bioconjugate chemistry · 2026Article
- In vivo tissue clearing with tartrazine and other dye molecules.Communications biology · 2026Review
- Advancing small-animal molecular imaging through multifaceted innovation.Journal of biomedical optics · 2026Article
- Photoacoustic Fingerprinting for Robust Molecular Imaging.bioRxiv : the preprint server for biology · 2026Article
- Tartrazine clears live cells while preserving viability at high refractive indices and osmolality.bioRxiv : the preprint server for biology · 2026Article
- Three-dimensional ex-vivo visualization of normal and inflamed small intestine and colonic tissue using optical coherence tomography.Scientific reports · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
Optical scattering in biological tissues presents a major challenge for achieving deep penetration in optical coherence tomography (OCT). Recent approaches leveraging the Kramers-Kronig (KK) relations suggest that strongly absorbing dyes can reduce scattering by modulating the tissue's refractive index. In this study, we investigate the use of indocyanine green (ICG), an FDA clinically approved near-infrared dye, as an optical clearing agent (OCA) for 1300 nm OCT imaging. Due to its strong absorption near 780 nm and its binding affinity to plasma proteins and lipids, ICG presents a promising candidate for KK-based optical clearing in fatty tissues. We validated ICG's clearing potential using 1300 nm OCT on the abdominal skin of a non-pigmented mouse for
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