Evidence map›Paper›PMID 40882008›Full record

ArticleAmerican journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists2026

Spaced learning versus traditional learning for pharmacists implementing β-lactam therapeutic drug monitoring.

Lindsay N Moreland-Head, Sara E Ausman, Christina G Rivera, Omar M Abu Saleh, Paul J Jannetto, Rebecca J Wessel, Erin F Barreto

Abstract readComparative Study
In one paragraph

Article in American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lindsay N Moreland-HeadIndiana University School of Medicine, West Lafayette, IN, USA.
Sara E AusmanDepartment of Pharmacy, Mayo Clinic Health System, Eau Claire, WI, USA.
Christina G RiveraDepartment of Pharmacy, Mayo Clinic, Rochester, MN, USA.
Omar M Abu SalehDivision of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-4955-5544
Paul J JannettoDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Rebecca J WesselStrategy Department, Mayo Clinic, Rochester, MN, USA.
Erin F BarretoDepartment of Pharmacy, Mayo Clinic, Rochester, MN, USA.

Funding

Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4M
Beta-lactam individualization for critically ill patientsK23AI143882 · NIAID · MAYO CLINIC ROCHESTER · PI BARRETO, ERIN FRAZEE · 2020 to 2024
$986k
NCATS NIH HHS UL1 TR002377NIAID NIH HHS K23 AI143882
6 · The paper itself

Abstract

purposeNo consistent recommendations exist on how best to educate pharmacists to facilitate implementation of new evidence-based practices. This study aimed to determine whether spaced learning was more effective than traditional education when learning a new evidence-based practice (β-lactam therapeutic drug monitoring, or TDM). SUMMARY: β-lactam TDM was implemented in a phased fashion at Mayo Clinic in Rochester. Two go-lives took place, separated by 6 months, which allowed for a natural experiment to test education delivery methods (traditional education in the first go-live group of pharmacists vs spaced learning in the second go-live group of pharmacists). Each group received the same base educational package, with pharmacists in the spaced learning group also offered monthly in-person sessions for 6 months before go-live to discuss key considerations and cases with experts. There was no difference between the spaced learning group and the traditional education group when assessing appropriate use of TDM as defined by (1) appropriate patient selection; (2) correct ordering of laboratory testing; (3) appropriate clinical action; and (4) completed documentation. Assessments of secondary knowledge transfer also showed no difference between the groups. Pharmacists in the different education groups had similar satisfaction scores related to the effect and utility of the education. Both spaced learning and traditional education were part of a comprehensive implementation plan for β-lactam TDM, which might have influenced the outcomes. Spaced learning for future pharmacist education efforts needs further study.

conclusionAs part of a greater β-lactam TDM implementation effort, altering the education delivery method did not impact the degree of knowledge transfer.

Indexed as

Anti-Bacterial Agentsbeta-LactamsDrug MonitoringEducation, Pharmacy, ContinuingPharmacistsAdultFemaleHumansLearningMaleMiddle AgedAnti-Bacterial Agentsbeta-Lactamsantibacterial agentspharmacistspharmacokineticspharmacy educationtherapeutic drug monitoring

Identifiers

PMID40882008
PMCPMC12694572

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.