Evidence map›Paper›PMID 40881963›Full record

ArticlePsychology of sexual orientation and gender diversity2025

Understanding differences in types of social support and their effects on mental health over time for trans and nonbinary adults.

Elliot Tebbe, Nadra E Lisha, Torsten B Neilands, Micah E Lubensky, Zubin Dastur, Mitchell R Lunn, Juno Obedin-Maliver, Annesa Flentje

Abstract read
In one paragraph

Article in Psychology of sexual orientation and gender diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elliot TebbeSchool of Nursing, University of Wisconsin-Madison.
Nadra E LishaCenter for Tobacco Control and Research and Education, University of California, San Francisco.
Torsten B NeilandsDivision of Prevention Science, Department of Medicine, University of California, San Francisco.
Micah E LubenskyCommunity Health Systems, School of Nursing, University of California, San Francisco.
Zubin DasturThe PRIDE Study/PRIDEnet, Stanford University School of Medicine.
Mitchell R LunnThe PRIDE Study/PRIDEnet, Stanford University School of Medicine.
Juno Obedin-MaliverThe PRIDE Study/PRIDEnet, Stanford University School of Medicine.
Annesa FlentjeCommunity Health Systems, School of Nursing, University of California, San Francisco.

Funding

PRIDEnet for the All of Us Research Program OT2OD025276 · OD · STANFORD UNIVERSITY · PI LUNN, MITCHELL RYAN, OBEDIN-MALIVER, JUNO · 2017 to 2024
$13.0M
Substance use and DNA methylation at the intersection of sex and genderR01DA052016 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FLENTJE, ANNESA · 2020 to 2023
$2.9M
Mentoring the next generation of substance use, HIV, and epigenetic researchers in sexual and gender minority healthK24DA057874 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Annesa Flentje · 2023 to 2026
$793k
NIDA NIH HHS K24 DA057874NIDA NIH HHS R01 DA052016NIH HHS OT2 OD025276
6 · The paper itself

Abstract

Although research has shown that social support generally is beneficial to mental health among trans and nonbinary (TNB) adults, less is known regarding what forms of support and the degree to which they mitigate the harms of minority stress on mental health over time. This study investigated differences in types of social support and their association with mental health over time in a sample of 2,411 TNB adults, predominantly younger in age (53% 18-30 years old), diverse in sexual orientation (97.5%, LGBQA+, 2.5% straight/heterosexual), gender identity (53.3% non-binary, 26% trans man, 12.4% trans woman), and similar in race and ethnicity to the US national population. We conducted a latent profile analysis (LPA) to identify social support typologies. A three-profile solution classified participants into a Low (39.6%), Moderate (40.7%), or High Support profile (19.7%). Significant variability in gender-related support experiences was noted for those in the Moderate and High Support profiles, while those in the Low Support profile had almost uniformly little to no support from family. Mental health outcomes differed between the profiles; Low Support participants reported significantly worse depression and PTSD symptoms; demographically, the greatest proportion of participants with marginalized identities clustered in the Low Support profile. Finally, we tested profile membership as a moderating variable in the association of minority stressors with mental health over time. Few significant differences emerged between groups, suggesting that being in a higher support profile may not necessarily buffer the harms of minority stress on mental health over time. Intervention implications are discussed.

Indexed as

latent profile analysisminority stressnonbinarysocial supporttransgender

Identifiers

PMID40881963
PMCPMC12380377

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.