ReviewFrontiers in human neuroscience2025
Excitation-inhibition imbalance in the motor control network: a key factor in post-stroke spasticity.
Review in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The effects of suspension-supported training on dynamic balance capacity in stroke patients: a systematic review and meta-analysis enhanced by XGBoost machine learning.Frontiers in medicine · 2026Pooled it
- Extracorporeal shock wave therapy for post-stroke spasticity: an umbrella review of systematic reviews and meta-analyses.Frontiers in neurologyPooled it
- Association of Cardiovascular Risk Burden with Cardiorespiratory Fitness and Functional Performance in Patients with Post-Stroke Spasticity: A Retrospective Observational Study.Journal of clinical medicine · 2026Article
- Early Treatment of Post-Stroke Spasticity with Botulinum Toxin Type A: Myth or Reality?Toxins · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spasticity is a recognized motor dysfunction that frequently arises following a stroke and significantly impacts the quality of life of affected patients. It is characterized by involuntary muscle activation resulting from overexcitation of the stretch reflex. Currently, therapeutic options for post-stroke spasticity are limited, and the underlying pathological mechanisms remain inadequately understood. Evidence suggests that stretch reflex hyperactivity is attributable to a combination of factors, including abnormal supraspinal projections, imbalances within the intraspinal network, and peripheral muscle alterations. This review aimed to examine supraspinal projections, specifically addressing the imbalance between excitatory and inhibitory output signals within the neural network of the brain's motor control region, and to discuss the significant role of the associated nerve bundles in the disease's pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.