ArticleWorld journal of clinical cases2025
Diagnostic accuracy of circulating miR-146, miR-221 and miR-222 in papillary thyroid cancer: A systematic review and meta-analysis.
Article in World journal of clinical cases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- An insilico analysis: three upregulated microRNAs as potential diagnostic biomarkers of Papillary Thyroid Carcinoma (PTC).Journal of the Egyptian National Cancer Institute · 2026Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPapillary thyroid cancer (PTC) often recurs following surgical excision, necessitating reliable long-term screening techniques after initial management. Ultrasound scans have a poor predictive value and biopsy and genetic testing have a low sensitivity. Biomarker detection, including thyroglobulin, has reduced accuracy as residual thyroid tissue remains following surgery. Serum/tissue microRNA detection offers a promising alternative to screen for thyroid malignancy. Based on our previous systematic review, miR-146, miR-221 and miR-222 appear most strongly associated with PTC.
aimTo perform a systematic review and meta-analysis, evaluating the use of circulating miR-146, miRNA-221 and miR-222 in PTC diagnosis and staging.
methodsA systematic literature search of MEDLINE, Scopus and the EMBASE library was performed. Human participants of any age, sex or geographical distribution were considered. Original studies assessing the diagnostic and prognostic accuracy of circulating serum miRNAs in histologically-confirmed PTC were included. Proportion and regression meta-analyses (logit-transformed) were conducted. PRISMA guidelines were followed throughout the process.
resultsAmong the 1530 studies screened, 6 met the inclusion criteria, reporting non-overlapping populations. For the diagnosis of PTC
conclusionmiRNA-146 and miRNA-222 were most sensitive, validating their efficacy in PTC diagnosis. Larger studies are needed for confident population generalisability. Use of two-MRNA types in conjunction needs to be assessed.
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