Evidence map›Paper›PMID 40881792›Full record

SynthesisFrontiers in neurology2025

The role of serum albumin and albumin-related nutritional indices in predicting post-stroke cognitive impairment: a systematic review and meta-analysis.

Yan-Qiu Wang, Xia He, Xia-Lian Huang, Fu-Li Qin, Feng-le Mao, Yue-Ming Cheng, Xiao-Xue Zeng, Ying-Ying Yang, Ming-Xi Xu

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Blood-Based Biomarkers for Post-Stroke Cognitive Impairment.Current issues in molecular biology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yan-Qiu WangSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Xia HeDepartment of Neurology, Affiliated Sichuan Provincial Rehabilitation Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Xia-Lian HuangDepartment of Neurology, Affiliated Sichuan Provincial Rehabilitation Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Fu-Li QinSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Feng-le MaoDepartment of Neurology, Affiliated Sichuan Provincial Rehabilitation Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yue-Ming ChengDepartment of Neurology, Affiliated Sichuan Provincial Rehabilitation Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Xiao-Xue ZengSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Ying-Ying YangSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Ming-Xi XuSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The role of serum albumin levels and albumin-related nutritional indices in the prediction of cognitive impairment after stroke has not reached a uniform conclusion. Methods: This study was prospectively registered in PROSPERO (CRD420251012150) and followed the PRISMA guidelines. We systematically searched six databases with a time frame from the date of database establishment to March 29, 2025. Literature selection and data collection were conducted by two researchers. Assessment of literature quality was performed according to the Newcastle-Ottawa Scale (NOS). Weighted mean difference (WMD) with 95% confidence intervals (CIs) was used to express pooled effect sizes. The chi-square (χ2) test (Cochran's Q) and index of inconsistency ( Results: A total of 9 studies involving 2,332 stroke patients were included in this meta-analysis. The results of this study showed that serum albumin levels (WMD: -3.85; 95% CI: -5.61, -2.09; Conclusion: Decreased serum albumin levels and albumin-related nutritional indices (GNRI and HALP scores) have a strong correlation with PSCI, which may become important indicators for early prediction of the development of PSCI. Systematic review registration: https://www.crd.york.ac.uk/prospero/#recordDetails, identifier, CRD420251012150.

Indexed as

cognitive impairmentnutritional indexpredictive biomarkersserum albuminstroke

Identifiers

PMID40881792
PMCPMC12382350

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.