SynthesisFrontiers in neurology2025
Association between constipation and risk of stroke: a systematic review and meta-analysis.
Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Impact of Constipation on Quality of Life, Work Productivity, and Treatment Practices: Findings from the CONNECT Web-Based Survey.Digestion · 2026Article
- New-onset constipation at acute stage after stroke: incidence, risk factors, and impact on stroke rehabilitation.Frontiers in neurologyArticle
- Mirror therapy combined with defecation motor imagery and repetitive transcranial magnetic stimulation improves post-stroke constipation: a retrospective study with EEG biomarker analysis.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This systematic review and meta-analysis aimed to evaluate the association between constipation and stroke risk, with subgroup analyses exploring effects on stroke subtypes. Methods: We systematically searched PubMed, Web of Science, and Cochrane Library until February 2025. Published studies reporting adjusted odds ratios (ORs), hazard ratios (HRs), or relative risks (RRs) for stroke in constipated versus non-constipated individuals were included. A random-effects model was used to pool effect estimates, with heterogeneity assessed via the chi-square test based on Cochrane Q statistics. Subgroup evaluations were conducted for stroke type (ischemic/hemorrhagic), region, study design, and sex. Results: Thirteen studies involving 684,123 constipation cases and 5,223,378 controls were analyzed. Constipation was associated with a 23% increased stroke risk (pooled OR = 1.23, 95% CI: 1.10-1.36, Conclusion: Our meta-analysis identified constipation as a risk factor for ischemic stroke, but not hemorrhagic stroke. These findings underscore constipation as a modifiable risk factor in ischemic stroke management, warranting further mechanistic and interventional studies. Systematic Review Registration: PROSPERO 2024; https://www.crd.york.ac.uk/PROSPERO/view/CRD42024615237.
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Registered trials
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