Evidence map›Paper›PMID 40881772›Full record

ArticleAnnals of statistics2024

MAXIMUM LIKELIHOOD FOR HIGH-NOISE GROUP ORBIT ESTIMATION AND SINGLE-PARTICLE CRYO-EM.

Zhou Fan, Roy R Lederman, Y I Sun, Tianhao Wang, Sheng Xu

Abstract read
In one paragraph

Article in Annals of statistics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Subspace Method of Moments forSIAM journal on imaging sciences · 2026
    Article
  4. Article
  5. Article
  6. Autocorrelation analysis for cryo-EM with sparsity constraints: Improved sample complexity and projection-based algorithms.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhou FanDepartment of Statistics and Data Science, Yale University.
Roy R LedermanDepartment of Statistics and Data Science, Yale University.
Y I SunDepartment of Statistics, University of Chicago.
Tianhao WangDepartment of Statistics and Data Science, Yale University.
Sheng XuDepartment of Statistics and Data Science, Yale University.

Funding

Reconstruction of heterogeneous and small macromolecules by cyro-EMR01GM136780 · NIGMS · PRINCETON UNIVERSITY · PI SINGER, AMIT · 2020 to 2023
$1.3M
NIGMS NIH HHS R01 GM136780
6 · The paper itself

Abstract

Motivated by applications to single-particle cryo-electron microscopy (cryo-EM), we study several problems of function estimation in a high noise regime, where samples are observed after random rotation and possible linear projection of the function domain. We describe a stratification of the Fisher information eigenvalues according to transcendence degrees of graded pieces of the algebra of group invariants, and we relate critical points of the log-likelihood landscape to a sequence of moment optimization problems, extending previous results for a discrete rotation group without projections. We then compute the transcendence degrees and forms of these optimization problems for several examples of function estimation under

Identifiers

PMID40881772
PMCPMC12382280

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.