Evidence map›Paper›PMID 40881673›Full record

ArticleDevice2025

Analysis and management of thermal loads generated in vivo by miniaturized optoelectronic implantable devices.

Mingzheng Wu, Kaiqing Zhang, Priscilla J Y Fok, Haohui Zhang, Andrew I Efimov, Yue Wang, Jingyuan Feng, Shupeng Li, Jianyu Gu, Xinyue Lu and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Device, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Mingzheng WuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Kaiqing ZhangDepartment of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.
Priscilla J Y FokQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Haohui ZhangDepartment of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.
Andrew I EfimovQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Yue WangQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Jingyuan FengQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Shupeng LiDepartment of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.
Jianyu GuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Xinyue LuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Dane HintermuellerQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Liangsong ZengQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Jinglan ZhangDepartment of Neurobiology, Northwestern University, Evanston, IL 60208, USA.
Emily A WatersDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Tianyu YangQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Jiaqi LiuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Glingna WangQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Zengyao LvDepartment of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.
Yuanting WeiDepartment of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.
Yiyuan YangDepartment of Biomedical Engineering & N.1 Institute for Health, National University of Singapore, Singapore 117456, Singapore.
Chad R HaneyDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Yevgenia KozorovitskiyDepartment of Neurobiology, Northwestern University, Evanston, IL 60208, USA.
Raudel AvilaDepartment of Mechanical Engineering, Rice University, Houston, TX, 77005, USA.
Abraham Vázquez-GuardadoDepartment of Electrical and Computer Engineering, North Carolina State University, Raleigh, NC 27606, USA.
Yonggang HuangQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
John A RogersQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
The Center for Label-free Imagingand Multiscale Biophotonics (CLIMB)P41EB031772 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Stephen A Boppart · 2022 to 2026
$7.6M
Training Program in Neurobiology of Information StorageT32MH067564 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniel A Dombeck · 2003 to 2026
$4.7M
Dynamic entanglements: the functional role and mechanistic basis of inter-individual neural synchronyU01NS131406 · NINDS · NORTHWESTERN UNIVERSITY · PI DONALDSON, ZOE REBECCA, KOZOROVITSKIY, YEVGENIA · 2023 to 2025
$4.2M
NCI NIH HHS P30 CA060553NIBIB NIH HHS P41 EB031772NIMH NIH HHS T32 MH067564NINDS NIH HHS U01 NS131406
6 · The paper itself

Abstract

Miniaturized implantable optoelectronic technologies for in vivo biomedical applications are gaining interest, but require strict thermal management for safe operation. Here, we introduce a comprehensive framework combining analytical solutions and numerical modeling to estimate and manage thermal effects of optoelectronic devices. We propose Green's functions to analytically solve temperature distributions in tissue from a point source with coupled thermal-optical power, capturing the influence of critical tissue properties and spatiotemporal parameters. Integrating the Green's function derives temperature distributions for sources with definable geometry. Numerical modeling defines scaling factors to account for variations in radiation patterns and material designs, enabling direct performance comparisons across systems. Guided by this framework, iterative optimization of a filamentary optogenetic probe for deep brain stimulation significantly reduces thermal loads while preserving typical behaviors in freely moving mice. Experimental validation through in vitro and in vivo characterization demonstrates scalable strategies to overcome thermal challenges in advanced bio-optoelectronic systems.

Identifiers

PMID40881673
PMCPMC12376052

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.