Evidence map›Paper›PMID 40881667›Full record

ArticleACS pharmacology & translational science2025

Hit-to-Lead Studies of Pyrazinylpiperazines against Visceral Leishmaniasis: Pharmacokinetic Profile and

Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Gisele Barbosa, Analu R Costa, Miguel Angel Chávez-Fumagalli, Thamires Quadros Froes, Priscila Zonzini Ramos, Paula Derksen Macruz, Thalita Carolyne Souza Trindade, Eduardo Jorge Pilau and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Thibault Joseph William Jacques Dit LapierreLaboratório de Síntese de Candidatos a Fármacos, Instituto de Química, Universidade Federal de Uberlândia (UFU), Uberlândia, MG 38400-902, Brazil.ORCID https://orcid.org/0000-0002-2347-9515
Mariza Gabriela Faleiro de Moura Lodi CruzGrupo de Genômica Funcional de Parasitos, Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ Minas), Belo Horizonte, MG 30190-002, Brazil.
Gisele BarbosaLaboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio ®), Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.
Analu R CostaLaboratório de Química Medicinal e Computacional (LQMC), Instituto de Física de São Carlos (IFSC), Universidade de São Paulo (USP), São Carlos, SP 13563-120, Brazil.
Miguel Angel Chávez-FumagalliComputational Biology and Chemistry Research Group, Vicerrectorado de Investigación, Universidad Católica de Santa María, Arequipa 04000, Peru.ORCID https://orcid.org/0000-0002-8394-4802
Thamires Quadros FroesLaboratory of Host-Parasite Interaction and Epidemiology Gonçalo Moniz Institute - Fiocruz - Bahia, Salvador, BA 40296-710, Brazil.ORCID https://orcid.org/0000-0001-7951-7560
Priscila Zonzini RamosCentro de Química Medicinal (CQMED), Centro de Biologia Molecular e Engenharia Genética (CBMEG), Universidade Estadual de Campinas (UNICAMP), Campinas, SP 13083-886, Brazil.
Paula Derksen MacruzLaboratório de Biomoléculas e Espectrometria de Massas (LaBioMass), Universidade Estadual de Maringá (UEM), Maringá, PR 807020-900, Brazil.
Thalita Carolyne Souza TrindadeLaboratory of Host-Parasite Interaction and Epidemiology Gonçalo Moniz Institute - Fiocruz - Bahia, Salvador, BA 40296-710, Brazil.
Eduardo Jorge PilauLaboratório de Biomoléculas e Espectrometria de Massas (LaBioMass), Universidade Estadual de Maringá (UEM), Maringá, PR 807020-900, Brazil.
Patricia Sampaio Tavares VerasLaboratory of Host-Parasite Interaction and Epidemiology Gonçalo Moniz Institute - Fiocruz - Bahia, Salvador, BA 40296-710, Brazil.
Maria Cristina NonatoCenter for the Research and Advancement in Fragments and molecular Targets (CRAFT), School of Pharmaceutical Sciences at Ribeirao Preto, University of São Paulo, Ribeirão Preto, SP 14040-903, Brazil.ORCID https://orcid.org/0000-0002-4916-1505
Katlin B MassirerCentro de Química Medicinal (CQMED), Centro de Biologia Molecular e Engenharia Genética (CBMEG), Universidade Estadual de Campinas (UNICAMP), Campinas, SP 13083-886, Brazil.ORCID https://orcid.org/0000-0001-6390-2560
Leonardo L G FerreiraLaboratório de Química Medicinal e Computacional (LQMC), Instituto de Física de São Carlos (IFSC), Universidade de São Paulo (USP), São Carlos, SP 13563-120, Brazil.ORCID https://orcid.org/0000-0002-6947-0639
Adriano D AndricopuloLaboratório de Química Medicinal e Computacional (LQMC), Instituto de Física de São Carlos (IFSC), Universidade de São Paulo (USP), São Carlos, SP 13563-120, Brazil.ORCID https://orcid.org/0000-0002-0457-818X
Lídia Moreira LimaLaboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio ®), Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.ORCID https://orcid.org/0000-0002-8625-6351
Silvane Maria Fonseca MurtaGrupo de Genômica Funcional de Parasitos, Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ Minas), Belo Horizonte, MG 30190-002, Brazil.
Celso de Oliveira Rezende JúniorLaboratório de Síntese de Candidatos a Fármacos, Instituto de Química, Universidade Federal de Uberlândia (UFU), Uberlândia, MG 38400-902, Brazil.ORCID https://orcid.org/0000-0003-1402-2035

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As part of the hit-to-lead optimization of antileishmanial pyrazinylpiperazines, the Absorption, Distribution, Metabolism, and Excretion (ADME) properties of the initial hit and five candidates for

Indexed as

lead discoverymechanism of actionpharmacokineticspyrazinylpiperazinesvisceral leishmaniasis

Identifiers

PMID40881667
PMCPMC12384620

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.