ReviewFrontiers in veterinary science2025
Emerging threats of HPAI H5N1 clade 2.3.4.4b in swine: knowledge gaps and the imperative for a One Health approach.
Review in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- A Novel Cell-Based High-Throughput Screening Model for Inhibitors Targeting Influenza Virus Hemagglutinin-α-2,6-Sialic Acid Interaction.Biomolecules · 2026Article
- Parameterization of the PA Endonuclease Bimetallic Center Reveals the Dynamics of Clinically Relevant Mutations.Journal of chemical theory and computation · 2026Article
- Bovine-derived H5N1 influenza virus efficiently infects lactating swine via the mammary gland.bioRxiv : the preprint server for biology · 2026Article
- Avian influenza overview December 2025-February 2026.EFSA journal. European Food Safety Authority · 2026Article
- Review
- Avian Influenza Viruses: Global Panzootic, Host Range Expansion and Emerging One-Health Threats.Veterinary sciences · 2026Review
- Early detection and genetic characterization of clade 2.3.4.4b H5N1 and H5N9 highly pathogenic avian influenza viruses at the onset of fall migration in wild birds during october 2025 in South Korea.Frontiers in cellular and infection microbiology · 2026Article
- Avian influenza overview September-November 2025.EFSA journal. European Food Safety Authority · 2025Article
- Electroporation and LNP-mediated delivery of plasmid DNA-encoded H5N1 influenza virus hemagglutinin support protection against highly pathogenic avian influenza.NPJ vaccines · 2025Article
- Avian influenza overview June-September 2025.EFSA journal. European Food Safety Authority · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Highly pathogenic avian influenza (HPAI) H5N1 represents a significant threat to wildlife, livestock, and public health. The recent detection of HPAI H5N1 clade 2.3.4.4b genotypes B3.13 and D1.1 in dairy cows, poultry, wild birds, wild mammals, and humans, along with the recent detection of D1.2 genotype in outdoor pigs, reflects an accelerated shift in the ecological and transmission dynamics of the virus. Given the pigs' role in influenza ecology, these shifts present a serious threat to the swine industry and public health, accentuating the urgency for a coordinated One Health response. However, the current understanding of swine influenza, particularly in preventing and preparing for potential HPAI H5N1 incursions, has not been fully discussed. Furthermore, the consequences of such incursions on the swine industry and consequently on public health have not been explored extensively. This review addresses the knowledge gaps related to HPAI H5N1 clade 2.3.4.4b infections in pigs. Assessing the risks of HPAI H5N1 in pigs and the consequences for cross-species transmission is crucial. Preventing the introduction of HPAI into pigs and minimizing spillover risks through evidence-based strategies is vital to ensuring food security, maintaining a safe food supply, sustaining animal production systems, and preventing human infections, including potential pandemics.
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