Evidence map›Paper›PMID 40881603›Full record

ArticleAdvanced functional materials2025

Matrix Tropism Influences Endometriotic Cell Attachment Patterns.

Hannah S Theriault, Hannah R C Kimmel, Alison C Nunes, Allison L Paxhia, Sarah Hashim, Kathryn B H Clancy, Gregory H Underhill, Brendan A C Harley

Abstract read
In one paragraph

Article in Advanced functional materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Hannah S TheriaultDept. of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Hannah R C KimmelDept. of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Alison C NunesCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Allison L PaxhiaDept. of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Sarah HashimDept. Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Kathryn B H ClancyCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Gregory H UnderhillDept. of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Brendan A C HarleyCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.

Funding

Gradient Biomaterials to Investigate Niche Regulation of HematopoiesisR01DK099528 · NIDDK · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Brendan A. Harley · 2014 to 2026
$4.0M
Synthetic manipulation of engineered perivascular nichesR01CA256481 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI HARLEY, BRENDAN A. · 2021 to 2025
$3.4M
Tissue microenvironment (TIMe) training programT32EB019944 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BHARGAVA, ROHIT, GASKINS, REX · 2016 to 2025
$1.9M
Microenvironmental Control of Liver Progenitor Cell Differentiation and Spatial PatterningR01DK125471 · NIDDK · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI UNDERHILL, GREGORY H · 2021 to 2024
$1.9M
Physiomimetic Models of Endometrioma InitiationR01HD118600 · NICHD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Kathryn Bridges Harley Clancy, Brendan A. Harley · 2025 to 2026
$1.3M
Interdisciplinary Research Training at the Interface of Reproductive Sciences and BioengineeringT32HD108075 · NICHD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Indrani C Bagchi, Amy J Wagoner Johnson · 2024 to 2026
$794k
NCI NIH HHS R01 CA256481NIBIB NIH HHS T32 EB019944NICHD NIH HHS R01 HD118600NICHD NIH HHS T32 HD108075NIDDK NIH HHS R01 DK099528NIDDK NIH HHS R01 DK125471
6 · The paper itself

Abstract

The initiation of endometriotic lesions is not well understood or characterized because endometriosis is typically diagnosed at an advanced stage. Endometriotic lesions are most often found on pelvic tissues and organs, especially the ovaries. To investigate the role of tissue tropism on ovarian endometrioma initiation, we adapted a well-characterized polyacrylamide microarray system to investigate the role of tissue-specific extracellular matrix and adhesion motifs on endometriotic cell attachment, morphology, and size. We report the influence of cell origin (endometriotic vs. non-endometriotic), substrate stiffness mimicking aging and fibrosis, and the role of multicellular (epithelial-stromal) cohorts on cell attachment patterns. We identify multiple ovarian-specific attachment motifs that significantly increase endometriotic (vs. non-endometriotic) cell cohort attachment that could be implicated in early disease etiology.

Indexed as

Endometriosisextracellular matrixlesion initiationtissue engineering

Identifiers

PMID40881603
PMCPMC12382958

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.