Synthesis of γ‑Lactams by Intermolecular (3 + 2) Annulation of Siloxy Alkynes and 3‑Aminooxetanes.

Xiang Li, Qiang Feng, Shuxuan Liu, Hai Huang, Zhengyu Han, Jianwei Sun

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Article in Precision chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Xiang LiJiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164, China.

Qiang FengDepartment of Chemistry and the Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration & Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon 999077, Hong Kong SAR, China.ORCID https://orcid.org/0000-0002-7032-0451

Shuxuan LiuJiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164, China.

Hai HuangJiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164, China.ORCID https://orcid.org/0000-0002-9732-1454

Zhengyu HanJiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164, China.ORCID https://orcid.org/0000-0001-8317-6439

Jianwei SunDepartment of Chemistry and the Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration & Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon 999077, Hong Kong SAR, China.ORCID https://orcid.org/0000-0002-2470-1077

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A silver-catalyzed intermolecular (3 + 2) annulation of siloxy alkynes and 3-aminooxetanes has been developed. This process provides mild and convenient access to useful γ-butyrolactams with high regio- and stereoselectivity. Mechanistically, intermolecular C-N bond formation likely precedes oxetane ring opening.

Indexed as

(3 + 2) Annulation3-AminooxetaneAnnulationSiloxy alkyneγ-Lactam

Identifiers

PMID40881594

DOI10.1021/prechem.5c00029

PMCPMC12381704

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