ArticleCureus2025
Ocular Syphilis Revisited: A Review of Cases and Evidence From the Literature.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis case series seeks to share our experience with ocular syphilis by reporting the clinical findings and management of nine diagnosed cases. MATERIALS AND
methodsThis retrospective case series comprises nine patients who presented to the Ophthalmology Department of Southampton General Hospital between 2013 and 2022. The series provides a comprehensive report on patients diagnosed with ocular syphilis, detailing the severity of the condition, associated symptoms, and the treatments administered.
resultsAll cases in the study were diagnosed with syphilis based on ocular findings. The patients exhibited a wide range of visual acuity, from normal to as low as light perception vision, with corresponding posterior segment results and varied intraocular pressure data. Some patients had recently been diagnosed with co-infection involving the human immunodeficiency virus. Except for one patient who underwent intravenous ceftriaxone treatment, the majority received systemic therapy with intravenous benzylpenicillin. In four cases, prednisolone was administered in conjunction with the systemic treatment. For topical therapy, three patients were provided with cycloplegics and topical steroids to alleviate discomfort and prevent iris adhesions.
conclusionsDiagnosing ocular syphilis presents challenges, which emphasizes the value of excluding syphilis infection in patients exhibiting uveitis, optic nerve neuritis or atrophy, acute muscular palsy, or visual loss. Ocular syphilis warrants consideration during diagnosis, necessitates treatment akin to neurosyphilis, and mandates testing for other immunodeficiency diseases. Inadequate management may lead to persistent vision impairment.
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