Evidence map›Paper›PMID 40881453›Full record

ArticleInternational journal of ophthalmology2025

Pars plana vitrectomy with tissue plasminogen activator for traumatic submacular hemorrhage.

Wilson X Wang, Kishan G Patel, Henok Getahun, Srishti Ramamurthy, Howard Chen, Raja Narayanan, Rajendra S Apte

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wilson X WangWashington University in St Louis School of Medicine, St. Louis, MO 63110, USA.
Kishan G PatelUT Southwestern Medical Center, Dallas, Texas 75390, USA.
Henok GetahunWashington University in St Louis School of Medicine, St. Louis, MO 63110, USA.
Srishti RamamurthyLV Prasad Eye Institute, Hyderabad, Telangana 500034, India.
Howard ChenWashington University in St Louis School of Medicine, St. Louis, MO 63110, USA.
Raja NarayananLV Prasad Eye Institute, Hyderabad, Telangana 500034, India.
Rajendra S ApteJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences; Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate visual outcomes of pars plana vitrectomy (PPV) combined with tissue plasminogen activator (tPA)-induced clot lysis and pneumatic displacement for submacular hemorrhage (SMH) in a cohort of closed-globe trauma patients.

methodsA retrospective, multicenter interventional case series involving 7 eyes of 7 patients who underwent PPV with subretinal tPA administration for SMH secondary to closed-globe injury were conducted. The primary outcome measure was the change in Snellen visual acuity.

resultsThe mean age of patients was 32y (range: 21-51y), with a mean follow-up duration of 4.6mo (range: 1.1-14.9mo). The average best-corrected visual acuity (BCVA) was 20/1020 at baseline and 20/114 at the final visit, respectively (

conclusionSurgical intervention involving tPA-mediated clot lysis and pneumatic displacement may yield visual benefits in trauma-induced SMH without underlying retinal vascular disease; however, larger prospective studies are warranted to confirm these findings.

Indexed as

clot lysispneumatic displacementsubmacular hemorrhagesubretinaltissue plasminogen activator

Identifiers

PMID40881453
PMCPMC12378688

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.