Evidence map›Paper›PMID 40881420›Full record

ArticleJACS Au2025

Enhancing Reaction Compatibility in Telescoped Multistep Flow Synthesis via Hybridizing Micro Packed-Bed/Micro Tubing Reactors: Application to Cyproflanilide and Broflanilide.

Xingyu Zhang, Gangqin Huang, Yihui Ou, Zeyi Luo, Zheyao Huang, Chenguang Liu, Fen-Er Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xingyu ZhangKey Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou 350108, China.
Gangqin HuangKey Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou 350108, China.
Yihui OuCollege of Chemical Engineering, Fuzhou University, Fuzhou 350108, P.R. China.
Zeyi LuoKey Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou 350108, China.
Zheyao HuangKey Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou 350108, China.
Chenguang LiuKey Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou 350108, China.ORCID https://orcid.org/0009-0009-4714-1250
Fen-Er ChenKey Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou 350108, China.ORCID https://orcid.org/0000-0002-6734-3388

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Telescoped multistep flow synthesis, which integrates sequential reactions into a seamless sequence without intermediate isolation, serves as a transformative force propelling the advancement of continuous drug manufacturing. However, interstep incompatibility caused by varying reaction conditions hinders its development and application. To address this critical challenge, we present a hybrid flow system combining micro packed bed reactors (μPBRs) and microtubular reactors (μTRs). μPBRs house heterogeneous catalytic processes, improving solvent and reagent compatibility and operational ease, while μTRs enable intensified homogeneous reactions with enhanced kinetics. This hybrid strategy was applied to the telescoped synthesis of

Indexed as

broflanilidecyproflanilidegreen synthesispharmaceutical continuous manufacturingtelescoped flow synthesis

Identifiers

PMID40881420
PMCPMC12381708

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.