ArticleFrontiers in surgery2025
Presacral tumors: a retrospective analysis of 112 cases with emphasis on diagnostic challenges and surgical outcomes.
Article in Frontiers in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mayo Clinic classification of presacral tumors: evolution of classifications and systematic review of pathologies.BJS open · 2026Pooled it
- Usefulness of ultrasound in diagnosing constipation in children: a narrative review.Frontiers in pediatrics · 2026Review
- Key H&E morphologic features associated with preoperative misdiagnosis of presacral neoplasms: a retrospective slide re-review study.Frontiers in oncology · 2026Article
- Presacral mucinous adenocarcinoma originating from a tailgut cyst: Diagnostic and therapeutic challenges in a rare entity.SAGE open medical case reports · 2025Article
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Authors and funding
4 authors.
Funding
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Abstract
Background: Presacral tumors are rare entities with heterogeneous pathology including malignant potential. Due to nonspecific symptoms mimicking common anorectal diseases, misdiagnosis remains a major challenge that may delay treatment and worsen prognosis, particularly for malignant variants. This study analyzes diagnostic pitfalls and surgical outcomes in a large single-center cohort. Methods: We retrospectively reviewed 112 presacral tumor cases treated at our tertiary colorectal center (2015-2025). Data included demographics, clinical presentation, misdiagnosis rates, imaging accuracy, surgical approaches, and complications. Statistical analysis utilized descriptive methods and Chi-square tests. Results: Among 112 patients (male 62, female 50; median age 52 years, range 18-93), 57% presented with anal/rectal pain, while 20.5% were asymptomatic. 85.7% of patients were referred from non-specialized centers. Misdiagnosis occurred in 29.5% (predominantly as anal fistula/abscess or pilonidal sinus). Preoperative imaging (MRI/CT) correctly diagnosed 60% of tumors >3 cm vs. 21.2% of smaller tumors ( Conclusion: High misdiagnosis rates (29.5%) data support for heightened suspicion in patients with "refractory perianal sepsis", especially given the potential for malignancy. MRI showed significantly higher diagnostic accuracy for tumors >3 cm. Transsacral/transanal resection is safe and effective for most cases (93.8%), with low major morbidity. Centralized management in specialized centers optimizes outcomes.
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