ArticlePregnancy (Hoboken, N.J.)2025
Hypertensive disorders of pregnancy and neuroimaging markers of dementia risk: A pilot study.
Article in Pregnancy (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Hypertensive Disorders of Pregnancy Associated With Cerebral Small Vessel Disease Decades Later.Journal of the American Heart Association · 2026Article
- Voxelwise correlation of neighbors as a hypothesis driven framework for characterizing white matter lesion heterogeneity.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Funding
Abstract
Background and Objectives: Hypertensive disorders of pregnancy (HDP) are associated with a long-term risk of maternal cognitive decline. Limited data exist regarding maternal brain structure in midlife after HDP. We examined the association between prior HDP and neuroimaging markers associated with microvascular brain injury, detected on high-resolution brain MRI. Methods: We conducted a pilot study embedded within the nuMoM2b Heart Health Study, a multicenter prospective cohort of nulliparous US individuals recruited between 2010 and 2013 in the first trimester of pregnancy. Participants with no history of HDP, preterm birth, small-for-gestational age infant, or stillbirth in any pregnancy, and participants with HDP in the index or any subsequent pregnancy were invited to undergo brain MRI at two study sites between December 21, 2021 and September 30, 2023, using a standardized protocol on identical scanners. Imaging outcomes of interest included white matter hyperintensity (WMH) volume, regional cerebral blood flow (CBF), fractional anisotropy (FA), radial diffusivity (RD), regional grey matter volume (GMV), and cortical thinning. Results: A total of 81 participants (mean age 39 years; 27% White, 9% non-Hispanic Black, 52% Hispanic, 10% Asian) had brain MRI, of whom 27 (33%) had a history of HDP. The median time from index delivery to MRI was 11 years. Participants with HDP had lower CBF in the left medial orbitofrontal, left inferior temporal, and right superior temporal lobes (Cohen's Discussion: Midlife individuals who experienced HDP had lower regional CBF and reduced white matter microstructural integrity, compared with those with no adverse pregnancy outcomes. Our results suggest that HDP are associated with long-term impairment of white matter structure and cerebrovascular function, potentially suggesting a mechanism underlying the association of HDP with risk of cognitive decline, and requiring further study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.