ArticleFrontiers in microbiology2025
Temporal dynamics of SARS-CoV-2 phylogenetic diversity in Central Brazil reveals evolutionary shifts among variants of concern during the pandemic.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Occlusion body-incorporated SARS-CoV-2 S-RBD via cypovirus polyhedrin-derived peptide: a novel insect cell-expressed antigen for high-accuracy COVID-19 diagnosis, and humoral immune response and hybrid immunity evaluation.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The COVID-19 pandemic has led to substantial health, economic, and social impacts worldwide, and now, after more than 5 years since the start of the pandemic, it is possible to retrospectively evaluate patterns of SARS-CoV-2 spread and its consequences. Here we investigate the temporal dynamics of SARS-CoV-2 phylogenetic diversity in Goiás State, Central Brazil, using genomic data from 8,937 viral sequences obtained from GISAID between March 2020 and October 2024. Phylogenetic diversity was assessed through median pairwise distances (MedPD) and phylogenetic eigenvector regression (PVR) derived from principal coordinate analysis (PCoA) of pairwise distances among sequences. Results show evolutionary shifts associated with the emergence of new variants of concern (VOCs), particularly Gamma and Omicron, corresponding to distinct peaks in phylogenetic diversity through time. The initial rise in MedPD coincided with the Gamma variant's emergence in early 2021, while a more pronounced peak followed the spread of the Omicron variant in late 2021. Although a third peak appeared in late 2023, it was based on smaller sample sizes and did not correspond to a major VOC. Moreover, the temporal dynamics of MedPD tends to mirror the epidemiological characterization of the epidemic over time, including morbidity and mortality, reflecting the impact of vaccination in the disease burden of subsequent variants. The strong phylogenetic signal over time, reflected in the first PCoA axis, highlights the evolutionary trajectory of the virus. This study illustrates how genomic surveillance provides critical insights into viral diversification and public health responses during pandemics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.