ArticleJournal of experimental orthopaedics2025
Decellularisation of human meniscus tissue using sodium dodecyl sulphate (SDS): Preserving biomechanical integrity for scaffold-based meniscal repair.
Article in Journal of experimental orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Natural Biomaterials for Osteochondral Repair: From Source to Strategy.Advanced healthcare materials · 2026Review
- Decellularisation of human meniscus tissue using sodium dodecyl sulphate (SDS): Preserving biomechanical integrity for scaffold-based meniscal repair.Journal of experimental orthopaedics · 2025Article
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8 authors.
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Abstract
Purpose: Meniscal tears are common knee injuries and a major risk factor for secondary osteoarthritis. Recently, there has been a paradigm shift toward meniscal preservation, reflecting the meniscus's vital role. In this context, tissue engineering approaches such as the development of meniscal scaffolds have gained attention. However, to reduce the immune response and improve biocompatibility, decellularization of allografts, while preserving the histoarchitectural and meniscal properties, is essential. The current study aimed to evaluate the effectiveness of decellularization and its impact on the biomechanical properties of the human meniscus. Methods: Twenty-one human meniscus specimens were collected between July and December 2023 during total knee arthroplasty. Preoperative MRI was performed to verify meniscal integrity. The specimens were decellularized using a sodium dodecyl sulphate (SDS) protocol and compared to native meniscus samples in terms of cell count, assessed through hematoxylin and eosin staining, and biomechanical properties, specifically Young's modulus, measured using a universal testing machine (Zwick Z010). Results: The cell count in the decellularized menisci was 11 cells/mm² (SD = 13; 95% CI: 2-20), representing a significant reduction compared to the native meniscus samples, which had a cell count of 111 cells/mm² (SD = 42; 95% CI: 81-141; Conclusions: This study demonstrated that the modified SDS-based decellularization protocol effectively decellularizes the human meniscus. Moreover, the decellularized tissue retained biomechanical properties comparable to those of native meniscus tissue. Tissue decellularization is a promising technique in regenerative medicine, enabling the use of scaffolds for tissue repair, particularly in applications such as meniscus transplantation following meniscectomy. Level of Evidence: Level III, controlled laboratory study.
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