Evidence map›Paper›PMID 40881242›Full record

ArticleWorld journal of clinical cases2025

Risk factors and outcomes of metastatic poorly differentiated thyroid carcinoma.

Chih-Wei Hsu, Chuen Hsueh, Yu-Ling Lu, Chia-Jung Hsu, Richard J Wong, Shu-Fu Lin

Abstract read
In one paragraph

Article in World journal of clinical cases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Multimodal spectrum of approach in poorly differentiated thyroid carcinoma (an updated analysis).Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chih-Wei HsuDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan 333, Taiwan.
Chuen HsuehDepartment of Pathology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
Yu-Ling LuDepartment of Internal Medicine, New Taipei Municipal TuCheng Hospital, New Taipei City 236, Taiwan.
Chia-Jung HsuDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan 333, Taiwan.
Richard J WongDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States.
Shu-Fu LinDepartment of Internal Medicine, New Taipei Municipal TuCheng Hospital, New Taipei City 236, Taiwan. mmg@cgmh.org.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPoorly differentiated thyroid carcinoma (PDTC) is a rare and aggressive form of thyroid cancer. Distant metastasis occurs frequently in PDTC.

aimTo determine factors associated with distant metastasis and the effects of metastasis, either diagnosed on initial presentation or developing during follow-up, on mortality in PDTC patients.

methodsPatients with PDTC diagnosed between January 1, 1985 and July 31, 2022 were identified using a thyroid cancer database at a medical center in Taiwan. Factors associated with distant metastasis and cancer-specific survival (CSS) were analyzed using binary logistic analysis and Cox regression, respectively. Survival analysis was conducted using the Kaplan-Meier method.

resultsThe study cohort included 39 patients with PDTC, including 16 with distant metastasis on initial presentation, 5 with metastasis during the follow-up period, and 18 with no evidence of metastasis. Older age (≥ 45 years) was significantly associated with a higher risk of distant metastasis (odds ratio: 5.31; 95% confidence interval: 1.27-22.2;

conclusionOlder patients with PDTC have an increased risk of distant metastasis. Patients with metastatic PDTC, both diagnosed at presentation and developing during follow-up, have a dismal prognosis.

Indexed as

AgeDistant metastasisLymph node metastasisPoorly differentiated thyroid carcinomaSurvival

Identifiers

PMID40881242
PMCPMC12243909

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.