Evidence map›Paper›PMID 40881227›Full record

ArticleWorld journal of methodology2025

Interleukin 10 supplement to reduce episodes of recurrent aphthous stomatitis.

Cinzia Casu, Angelo Michele Inchingolo, Germano Orrù

Abstract readEditorial
In one paragraph

Article in World journal of methodology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cinzia CasuDepartment of Surgical Science, Oral Biotechnology Laboratory, University of Cagliari, Cagliari 09124, Italy. ginzia.85@hotmail.it.
Angelo Michele InchingoloDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari "Aldo Moro", Bari 70124, Italy.
Germano OrrùDepartment of Surgical Science, Oral Biotechnology Laboratory, University of Cagliari, Cagliari 09124, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent aphthous stomatitis (RAS) is a very frequent condition in developed countries whose basic symptom is a lesion referred to as an aphthous ulcer. High levels of interleukin (IL)-1 and IL-6 and low salivary levels of IL-10 are the basis of RAS pathogenesis. Sublingual supplements based on IL-10 can be very useful in reducing the phenomenon of aphthous recurrence in patients with RAS. An observational clinical experience with a group of 5 patients with RAS receiving a commercially available IL-10-based supplement was reported by the authors. The findings revealed a subsequent reduction in the incidence of mouth ulcers.

Indexed as

AphthosisInterleukinInterleukin 10Low-dose medicineRecurrent aphthous stomatitis

Identifiers

PMID40881227
PMCPMC11948208

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.