Evidence map›Paper›PMID 40881200›Full record

ArticleThe Linacre quarterly2025

The Brain as a Whole? Neuroendocrine Functions and Death by Neurological Criteria.

Samuel Berendes

Abstract read
In one paragraph

Article in The Linacre quarterly, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Samuel BerendesAlbert Gnaegi Center for Health Care Ethics, Saint Louis University, MO, USA.ORCID https://orcid.org/0009-0000-2395-4008

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Death by neurological criteria, often referred to as "brain death," has been the source of significant controversy in the past decades. The legal definition of brain death focuses on the irreversible loss of all brain function, including the brain stem, leading to an understanding of whole-brain death. Of particular importance for the brain death debate, the American Academy of Neurology has recently asserted that the loss of neuroendocrine function is not necessary for brain death determination. The question becomes whether it is consistent with a sound anthropology to accept brain death despite continuing neuroendocrine function. I argue that it is, as neuroendocrine function depends on the brain as a whole. This will be shown through engaging with the writings of Thomas Aquinas, especially as they relate to a hylomorphic understanding of the human person. Additionally, I will engage with understandings of brain death as the loss of the integrative unity of the human organism, particularly with Maureen Condic's distinction between integration and coordination. Through this, I will demonstrate that arguments that neuroendocrine functions do not in themselves constitute a vital function but, rather, depend on the brain as a whole.

Indexed as

anthropologybrain deathdetermination of deathneuroendocrine systemsneurologyorganismphilosophysystems integrationtheology

Identifiers

PMID40881200
PMCPMC12378257

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.