SpaCE: a spatial counterfactual explainable deep learning model for predicting out-of-hospital cardiac arrest survival outcome.

Understanding the relationship between risk factors, geospatial patterns, and disease outcomes is essential in health geography research. These relationships can inform the implementation of healthcare and public health strategies to improve health outcomes. To accurately uncover such complex relationships, it is necessary to have a predictive model capable of integrating both health variables and spatial information to forecast health outcomes, along with a tool to interpret and reveal the patterns identified by this model. We developed a Spatial Counterfactual Explainable Deep Learning model (SpaCE), comprising a spatially explicit health outcome predictor and a prototype-guided counterfactual explanation. The SpaCE model unifies geospatial and health variables to improve predictions and generates hypothetical examples with minimal changes but opposite outcomes. Using these counterfactuals, SpaCE assesses the impact of each variable in different spatial contexts. We evaluated the model for predicting cardiac arrest survival outcomes. With a 0.682 AUCROC score, the SpaCE exceeds baseline models by 10.2%. Further analysis also reveals that the geospatial context significantly affects how various risk factors affect the survival outcomes of patients. Overall, the SpaCE model significantly improves predictive accuracy and explainability. It provides targeted interventions at both individual and geographic levels, and the cardiac arrest case study shows its high adaptability to various disease scenarios.