Evidence map›Paper›PMID 40881136›Full record

ArticleAdvanced materials interfaces2025

Hybrid DNA Origami - Graphene Platform for Electrically-Gated Nanoscale Motion.

João D G Azevedo, Tiago Queirós, Filipe Camarneiro, Maria João Lopes, João Freitas, Agnes Purwidyantri, Praneetha Sundar Prakash, Soumya Chandrasekhar, Thorsten-Lars Schmidt, Pedro Alpuim and 1 more

Abstract read
In one paragraph

Article in Advanced materials interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Engineering two-dimensional electronic biosensors.Nature reviews electrical engineering · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

João D G AzevedoINL - International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, 4715-330, Braga, Portugal.
Tiago QueirósINL - International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, 4715-330, Braga, Portugal.
Filipe CamarneiroINL - International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, 4715-330, Braga, Portugal.
Maria João LopesINL - International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, 4715-330, Braga, Portugal.
João FreitasINL - International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, 4715-330, Braga, Portugal.
Agnes PurwidyantriINL - International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, 4715-330, Braga, Portugal.
Praneetha Sundar PrakashPhysics Department, 103 Smith Hall, Kent State University, Kent, OH, 44242, United States of America.
Soumya ChandrasekharPhysics Department, 103 Smith Hall, Kent State University, Kent, OH, 44242, United States of America.
Thorsten-Lars SchmidtPhysics Department, 103 Smith Hall, Kent State University, Kent, OH, 44242, United States of America.
Pedro AlpuimINL - International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, 4715-330, Braga, Portugal.
Jana B NiederINL - International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, 4715-330, Braga, Portugal.

Funding

Small and Mechanosensitive Membrane Proteins Studied with DNA-based ToolsR35GM142706 · NIGMS · KENT STATE UNIVERSITY · PI SCHMIDT, THORSTEN LARS · 2021 to 2025
$2.1M
NIGMS NIH HHS R35 GM142706
6 · The paper itself

Abstract

We present a proof-of-principle device for axial high-resolution operation that combines a deoxyribonucleic acid (DNA) origami with a functionalized graphene layer, analyzed by nanoscopy. Along the DNA origami structure, we bind ATTO-488 fluorophores at specific distances from graphene, from where we expect specific fluorescence lifetime values due to nearfield energy transfer processes. These are characterized by Fluorescence Lifetime Imaging Microscopy (FLIM). Through modulation of the electrostatic potential of graphene under electrical gating, we observe changes in the fluorescence lifetimes. These are understood as the result of changed energy transfer coupling conditions between the fluorophore and graphene's electronic states, combined with a vertical displacement of the DNA origami structure that matches molecular dimensions. We provide a hybrid architecture whose nanoscale operation depends on the applied voltage regime. A potential application of these findings may be envisioned for biocompatible sensing approaches, in medical or environmental sensing.

Indexed as

biosensorsDNA origamifluorescence quenchinggraphenenearfield sensing

Identifiers

PMID40881136
PMCPMC12382438

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.