ArticleWorld journal of clinical cases2025
Medial olivocochlear reflex dysfunction in multiple sclerosis: The influence of brainstem lesion localization and its clinical implications.
Article in World journal of clinical cases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMultiple sclerosis (MS) is known to affect many sensory systems, yet most auditory research in MS has focused on the afferent pathways, with relatively few studies examining efferent function. The brainstem is a common site for MS plaques, and the medial olivocochlear (MOC) system is located in the superior olivary complex (SOC) of the brainstem. The cochlear nuclei are also involved in the MOC reflex arc. Additionally, the temporal cortex can modulate the SOC and cochlear nucleus, so lesions in the brainstem or temporal cortex may affect the MOC reflex in MS.
aimTo investigate efferent auditory system activity in patients with multiple sclerosis
methodsThe study included 50 patients with MS and 50 healthy controls. Patients with MS were divided into three subgroups according to cranial magnetic resonance imaging findings: Patients with brainstem lesions (Group 1,
resultsThere was no significant difference in pure-tone hearing thresholds or baseline TEOAE amplitudes between the MS and control groups, indicating normal cochlear function in patients with MS; however, MOC reflex suppression was significantly reduced in patients with MS compared to controls (
conclusionThe findings indicate that the efferent auditory system (specifically the MOC reflex) is affected by MS. MOC reflex activity was most significantly decreased in patients with MS with brainstem lesions, while temporal cortex lesions alone did not appear to notably impair the MOC reflex. Diminished MOC activity may underlie various auditory difficulties in patients with MS (
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