Evidence map›Paper›PMID 40880997›Full record

ReviewChemical & biomedical imaging2025

Signal Transduction Strategies for DNAzyme-Based Sensing and Imaging of Metal Ions in Cells and

Whitney Lewis, Annie Farrell, Shreestika Pradhan, Yi Lu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chemical & biomedical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Bioimaging of Metals.Chemical & biomedical imaging · 2026
    Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Whitney LewisDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID https://orcid.org/0000-0003-1203-6441
Annie FarrellDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID https://orcid.org/0009-0003-1023-9728
Shreestika PradhanDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID https://orcid.org/0009-0005-5216-5004
Yi LuDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID https://orcid.org/0000-0003-1221-6709

Funding

Design and Selection of Novel Metalloenzymes for Biocatalysis, Bioimaging, and Genetic EngineeringR35GM141931 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Yi Lu · 2021 to 2026
$3.5M
NIGMS NIH HHS R35 GM141931
6 · The paper itself

Abstract

Metal ions play crucial roles in biological processes, and their dysregulation can lead to various diseases. Understanding the distribution of these metal ions provides deeper insight into their roles in both health and disease. DNAzymes offer a general approach for detecting nearly any metal ion within cells and

Indexed as

bioluminescencecellular imagingDNAzymesfluorescence techniquesin vivo metal ion detectionmetal ion dysregulationmetal ion sensingsignal transduction strategies

Identifiers

PMID40880997
PMCPMC12381729

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.