Evidence map›Paper›PMID 40880993›Full record

ArticleMicrofluidics and nanofluidics2024

High throughput cell mechanotyping of cell response to cytoskeletal modulations using a microfluidic cell deformation system.

Ian M Smith, Jeanine A Ursitti, Sai Pranav Majeti Venkata, Nikka Givpoor, Megan B Stemberger, Autumn Hengen, Shohini Banerjee, Khaled Hached, Siem van der Laan, Joseph Stains and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microfluidics and nanofluidics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Acute priming using elevated fluid viscosity recovers 'bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Ian M SmithFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Jeanine A UrsittiUniversity of Maryland School of Medicine, Department of Orthopedics, Baltimore, MD 21201.
Sai Pranav Majeti VenkataFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Nikka GivpoorFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Megan B StembergerDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Autumn HengenFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Shohini BanerjeeFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Khaled HachedMT-act, CRBM, Montpellier, France.
Siem van der LaanMT-act, CRBM, Montpellier, France.
Joseph StainsUniversity of Maryland School of Medicine, Department of Orthopedics, Baltimore, MD 21201.
Stuart S MartinDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Christopher WardUniversity of Maryland School of Medicine, Department of Orthopedics, Baltimore, MD 21201.
Kimberly M StrokaFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.

Funding

UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANTP30CA134274 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI FEYRUZ VIRGILIA RASSOOL · 2008 to 2026
$51.0M
University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ALICE S. RYAN · 2006 to 2026
$28.9M
Tubulin microtentacles in detached mammary epithelial cellsR01CA124704 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI MARTIN, STUART S · 2007 to 2025
$5.7M
Exploring mechanisms of aquaporin-mediated cell migrationR35GM142838 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI STROKA, KIMBERLY · 2021 to 2025
$1.9M
NCI NIH HHS P30 CA134274NCI NIH HHS R01 CA124704NIA NIH HHS P30 AG028747NIGMS NIH HHS R35 GM142838
6 · The paper itself

Abstract

Cellular mechanical properties influence cellular functions across pathological and physiological systems. The observation of these mechanical properties is limited in part by methods with a low throughput of acquisition or with low accessibility. To overcome these limitations, we have designed, developed, validated, and optimized a microfluidic cellular deformation system (MCDS) capable of mechanotyping suspended cells on a population level at a high throughput rate of ~300 cells per second. The MCDS provides researchers with a viable method for efficiently quantifying cellular mechanical properties towards defining prognostic implications of mechanical changes in pathology or screening drugs to modulate cytoskeletal integrity.

Indexed as

cytoskeletonmechanotypingmicrofluidic

Identifiers

PMID40880993
PMCPMC12382600

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.