Evidence map›Paper›PMID 40880988›Full record

ArticlemicroPublication biology2025

Functional Analysis of the Yeast Counterpart to the Human GCN2 p.Glu738_Asp739insArgArg Variant.

Anja H Schiemann, Makhdoom Sarwar, Evelyn Sattlegger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in microPublication biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anja H SchiemannSchool of Food Technology and Natural Sciences, Massey University, Palmerston North, New Zealand.
Makhdoom SarwarMaurice Wilkins Centre for Molecular BioDiscovery, University of Auckland, Auckland, New Zealand.
Evelyn SattleggerSchool of Food Technology and Natural Sciences, Massey University, Palmerston North, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GCN2, a cytoplasmic protein kinase, helps cells adapt to nutrient deprivation and is implicated in various cancers. The GCN2 p.Glu738_Asp739insArgArg variant was found to be significantly enriched in a cohort of early-onset colorectal cancer cases, indicating possible lineage-associated predisposition. Introducing an equivalent variant into the yeast model

Identifiers

PMID40880988
PMCPMC12381657

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.