Evidence map›Paper›PMID 40880983›Full record

ArticleAperture neuro2024

Application of hyperalignment to resting state data in individuals with psychosis reveals systematic changes in functional networks and identifies distinct clinical subgroups.

Zachary Anderson, Jessica A Turner, Yoni K Ashar, Vince D Calhoun, Vijay A Mittal

Abstract read
In one paragraph

Article in Aperture neuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zachary AndersonDepartment of Psychology, Northwestern University, Evanston IL.
Jessica A TurnerDepartment of Psychiatry and Behavioral Health, Wexner Medical Center, Ohio State University, Columbus OH.
Yoni K AsharAnschutz Medical Center, University of Colorado, Denver CO.
Vince D CalhounPsychology Department and Neuroscience Institute, Georgia State University, Atlanta GA.
Vijay A MittalDepartment of Psychology, Northwestern University, Evanston IL.

Funding

TRAINING PROGRAM IN THE NEUROSCIENCE OF HUMAN COGNITIONT32NS047987 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Rodrigo M Braga, Christina Maria Zelano · 2006 to 2026
$5.6M
SchizConnect: Large-Scale Schizophrenia Neuroimaging Data Mediation & FederationU01MH097435 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AMBITE, JOSE LUIS, POTKIN, STEVEN G · 2013 to 2016
$2.0M
Graduate Training Program for Magnetic Resonance ImagingT32EB025766 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Michael Markl · 2019 to 2026
$1.6M
NIBIB NIH HHS T32 EB025766NIMH NIH HHS U01 MH097435NINDS NIH HHS T32 NS047987
6 · The paper itself

Abstract

Psychosis related disorders are severe and difficult to define with brain-based biomarkers due, in part, to heterogeneous psychosis symptoms and individual differences in the brain. Recent innovations in computational neuroscience may address these difficulties. Hyperalignment aligns voxel-wise patterns of neural activity across individuals to improve signal in brain data. Transformation metrics may also serve as biomarkers that reflect clinically relevant differences in pattern connectivity (scale), baseline connectivity (translation), and network topography (rotation). In the present study, we apply hyperalignment to resting state functional connectivity between the frontal cortex and regions throughout the brain in a sample of individuals diagnosed with psychosis and healthy controls. We used binary class support vector machines (SVM) to classify psychosis using unaligned (accuracy=66.50%,

Indexed as

hyperalignmentpsychosisresting state fMRIschizoaffective disorderschizophrenia

Identifiers

PMID40880983
PMCPMC12382791

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.