ArticleEJHaem2025
Alpha-Globin Gene Triplication in Central Thailand: Prevalence, Haematological Findings and Clinical Impact With Co-Inherited Beta-Globin Mutations.
Article in EJHaem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Molecular profiling of thalassemia in Southeastern Romania.Journal of hematopathology · 2026Article
- Clinical phenotypic heterogeneity in pediatric-thalassemia carriers co-inherited with-globin gene triplication.Annals of hematology · 2026Article
- Article
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4 authors.
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Abstract
Objectives: We aimed to ascertain the prevalence of ααα Materials and Methods: We performed a retrospective review of adult (≥ 18 years) samples submitted for polymerase chain reaction-based α-globin mutation analysis at Siriraj Hospital, Mahidol University, Bangkok (January 2012-December 2021). Haematological indices were compared between carriers and non-carriers of α-globin triplications, and clinical severity was assessed in those with co-inherited β-globin mutations. Results: Among 1559 subjects, α-globin triplication prevalence was 1.28%, with ααα Conclusions: Although uncommon in central Thailand, α-globin triplications can exacerbate anaemia in individuals with co-inherited heterozygous β-globin mutations, supporting routine screening in symptomatic cases.
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