Evidence map›Paper›PMID 40880896›Full record

ArticleNature reviews bioengineering2025

Implantable bioelectronic devices for photoelectrochemical and electrochemical modulation of cells and tissues.

Jiuyun Shi, Pengju Li, Saehyun Kim, Bozhi Tian

Abstract read
In one paragraph

Article in Nature reviews bioengineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Soft electroceutical immunomodulation.National science review · 2026
    Article
  8. Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  9. Complementary biomolecular coassemblies direct energy transport for cardiac photostimulators.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiuyun ShiDepartment of Chemistry, University of Chicago, Chicago, IL, USA.ORCID 0000-0003-1949-0348
Pengju LiPritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-0327-4758
Saehyun KimDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Bozhi TianDepartment of Chemistry, University of Chicago, Chicago, IL, USA.ORCID 0000-0003-0593-0023

Funding

Multi-site photostimulation devices using porosity-based semiconductor heterojunctions for cardiac resynchronization therapyR01EB036091 · NIBIB · UNIVERSITY OF CHICAGO · PI Narutoshi Hibino, Bozhi Tian · 2024 to 2026
$1.8M
NIBIB NIH HHS R01 EB036091
6 · The paper itself

Abstract

Electroceuticals are bioelectronic devices that provide or modulate electrical or electrochemical signals to regulate physiological functions. In particular, devices designed for energy conversion are capable of transforming electrical energy into alternative forms of energy, such as heat or light, or vice versa, thereby enabling the photoelectrochemical and electrochemical modulation of biological systems, for example, to control muscle movement or cardiac rhythm. Such energy conversion approaches offer remote control and enhanced precision, surpassing the limitations of direct tissue and cell stimulation with traditional electroceutical devices, such as pacemakers, including mechanical mismatch at interfaces and wired communication. In this Review, we explore the fundamental principles of photoelectrochemical and electrochemical modulation of cells and tissues, emphasizing behaviour under physiological conditions. We then examine the development and application of implantable bioelectronics that use photoelectrochemical and electrochemical processes for modulation. Finally, we discuss future directions for energy conversion devices in implantable electroceuticals.

Identifiers

PMID40880896
PMCPMC12381665

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.